Scientists have identified how and why some Covid-19 patients develop life-threatening blood clots. This can lead to targeted therapies that prevent this.
The study, led by researchers at the RCSI University of Medical and Health Sciences, Journal of Thrombosis and Haemostasis.
Previous studies have demonstrated that blood clotting is a significant cause of death in Covid-19 patients. To understand why the coagulation occurs, researchers analyzed blood samples taken from patients with Covid-19 in the Intensive Care Unit at Beaumont Hospital in Dublin.
They found that the balance between a coagulation-causing molecule called von Willebrand Factor (VWF) and its regulator called ADAMTS13 was severely disrupted in patients with severe Covid-19.
When compared to the control group, the blood of Covid-19 patients had higher levels of procoagulant VWF molecules and lower levels of anticoagulant ADAMTS13. In addition, researchers have identified other changes in the protein that caused the reduction of ADAMTS13.
“Our research helps provide insights into the mechanisms that cause severe thrombosis in Covid-19 patients, which is important for developing more effective treatments.” Vascular biology at RCSI.
“Further research is needed to determine if targets aimed at modifying ADAMTS13 and VWF levels lead to successful therapeutic interventions, but continue to develop treatments for Covid-19 patients. It is important that the Covid-19 vaccine remains unavailable to many people around the world, so it is important to provide effective treatment for them and patients with breakthrough infections. “
This work is the COVID-19 Rapid Response Award of the Health Research Commission and the charity from the 3M Foundation to the RCSI Medical and Health Science University to support the COVID-19 research by the Irish COVID-19 Angiopathy Research (ICVS) Funded by a grant. ..
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