As the pandemic continues to slow, the fight against ‘long hauler’ conditions persist

Related video above: COVID-19 long-hauler joins vaccination efforts after near-death experience Dr. Michael Saag normally cares for COVID-19 patients, but early in the pandemic, he became a patient. Now, he has joined the ranks with lingering symptoms from a condition doctors are still trying to understand.In Saag’s case, COVID-19 was never so bad he had to be hospitalized, but he spent 15 days isolated in his room, and he got better — mostly.His brain fog persisted. He was easily out of his breath. His heart raced. These symptoms lasted six weeks post-infection.Saag felt good enough to go back to work at University of Alabama Birmingham, but even after other symptoms cleared up, he experienced hearing loss and now wears hearing aids.”It’s frustrating,” he said ruing a Centers for Disease Control and Prevention’s Clinical Outreach and Communication Activity meeting Thursday.Saag said he has met other patients with ongoing symptoms who are frustrated, too.”They’d gone to their providers who said, this is in your head, or this is not something to be worried about, but it was pretty profound,” Saag said.People sometimes called “long haulers” experience long COVID, post-COVID conditions, post-COVID syndrome — there’s no settled name. There’s also no diagnostic test, no specific treatment, no pill to take. And while research is ongoing, there aren’t large, peer-reviewed, gold-standard clinical trials yet either.Some people get better on their own over time, or symptoms can be treated, but for others, recovery remains elusive.This week, the American Medical Association adopted a policy to educate physicians and students on post-viral syndromes following COVID-19.Also this week, the CDC also posted interim guidance meant to help doctors better evaluate patients with post-COVID-19 conditions, even with so much uncertainty around them.100 symptoms and little consistencyPost-COVID-19 is an umbrella term that describes a variety of physical and mental problems that can follow four or more weeks after a COVID-19 infection, according to the CDC.There are potentially hundreds of symptoms, including shortness of breath, fatigue, headache, fever, anxiety, depression, pain, a loss of taste and smell, difficulty thinking, a racing heart and many others.Symptoms are not consistent. Doctors can’t predict what symptoms someone will have or who will get them, and symptoms can change over time, or disappear and then come back.Sometimes, the fix seems relatively simple. Dr. Mitchell Miglis, an autonomic disorders specialist who works with post-COVID-19 patients at Stanford Health Care said there are cases where he reminds people to watch their salt, or increase their fluids, or prescribes a beta-blocker, and they eventually get better.”We first try to control the symptoms and then use that as a bridge to get them more physically active and then treat all the components that we can,” Miglis said.But not all symptoms are that easy to address. “We don’t really have a single treatment that addresses the underlying disease, because we still don’t know what’s causing the underlying disease,” Miglis said.Millions might be affectedIt’s not totally clear how many people have it, either. In April, the National Institutes of Health Director Dr. Frances Collins told Congress preliminary research found about 10 to 30% of people who had COVID-19 may develop long-term health issues.One white paper study from FAIR Health published Tuesday looked at private insurance records for nearly 2 million COVID-19 patients and concluded nearly a quarter, 23.2%, had at least one post-COVID-19 condition 30 or more days after initial diagnosis. With more than 33 million COVID-19 cases counted in the United States since the start of the pandemic, there could be millions facing ongoing symptoms.”That’s probably an underestimate,” said Leonard Jason, a professor of psychology who works on the issue of brain fog with post-COVID-19 patients at DePaul University in Chicago. He wants doctors to watch out for these patients so they get appropriate care.”There’s probably a lot of people who have gotten this and not been identified. That’s one issue, how do we even come up with the criteria of what it means to be a long hauler?” Jason said. “There’s not a lot of consensus at this point, which is a problem.”Who are the long haulers?The FAIR Health study that looked at insurance records between February and December 2020 found the post-COVID-19 conditions were more common among patients with more severe COVID-19, but a “substantial” share of asymptomatic cases also had long-term symptoms. More research is needed, it said.Most of the post-COVID-19 conditions studied were more common in females, yet there were 12 symptoms more common among men.”I’ve been struck by how many people have no underlying conditions, in fact, a couple marathon runners that are young in the 20s and 30s. They come back with post-COVID-19 conditions that they have trouble sometimes just standing in the shower,” Saag said about some of the patients he treated.What’s being doneIn February, the NIH launched an initiative to identify the cause, the prevention, and treatments for post-COVID-19 condition. In December, Congress provided $1.15 billion in funding over four years to support the NIH research.The American Medical Association policy adopted this week also called for advocacy for more funding for research, prevention, control and treatment.For now, a person feeling long COVID-19 symptoms may be able to receive care from their regular doctor, or one of the post-COVID-19 care clinics that have opened around the country. During a call with clinicians this week, the CDC said most conditions can be identified and managed by a person’s primary care doctor, in coordination with specialists and such clinics.The post-COVID-19 clinics see signs of hopeMount Sinai’s Center for Post-Covid Care in New York, one of the first such clinics to launch, has been busy. By February, doctors had already seen 1,600 patients. These days, David Purtino, a physical therapist who helps patients run the clinic, is feeling a new sense of hope.”When I was speaking to the media three months ago, I would say everyone is improving, and we’re encouraged by how their improving, but there’s not a single person that’s beyond COVID,” said Purtino. “Now, after months and months of working and perfecting this, we have dozens of individuals that we’ve now discharged telling us they feel like they did before COVID. This is a new development.”For many patients, it hasn’t been easy. On average, he said, it’s 100 days of therapy. “It’s a long process, very slow, very incremental therapy, twice a week, and people need to make a lot of behavioral and life adjustments along the way to avoid symptoms triggers and exacerbations,” Purtino said. “But you know, we feel pretty encouraged that we’re finally getting some traction.”Not everyone takes that long to heal. Dr. Panagis Galiatsatos, a pulmonary and critical care medicine physician who treats patients at Johns Hopkins Post COVID-19 Care clinic said some people get better in about three months.”I tell them it’s like when you break a bone. If we take the cast off, it’s not going to be ready to run right off the bat. You’ve got to rehab it, and it’s going to be uncomfortable, but it will get better,” Galiatsatos said.Another category of patient develops symptoms that can be treated that are more pulmonary-specific, like asthma.”Everything from brain to feet can be affected,” Galiatsatos said. Some people also need mental health care.”The last category of patients we see have symptoms that don’t fit an actual disease process that we are aware of,” Galiatsatos said. He tells them they’ll figure it out together.One patient he treated compared it to how good doctors treated AIDS in the ’80s.”Sometimes we have to do a little bit of outside the box thinking on how best to help,” Galiatsatos said. “But I have confidence we can.”

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