Health
New ovarian cancer treatment attempts result in tumor shrinkage in almost half of patients, researchers say
New treatment for advanced forms of Ovarian cancer According to researchers, it is “very effective” in shrinking tumors.
The combination of VS-6766 and de factinib showed a significant response in 11 of 24 patients (46%) during a small phase I trial.
It worked even better in patients with tumors caused by KRAS mutations, with 64% of patients responding to treatment.
Researchers said they were “satisfied” with the results, suggesting that if the results were reproduced in larger trials, they could mean “significant progress” in treatment.
This study was led by a team at the institute cancer Research in London and The (ICR) Royal Marsden NHS Foundation Trust.
It included patients with low-grade serous ovarian cancer, which is less common and tends to develop at a younger age.
According to the ICR, less than 13% of patients with this form of the disease respond to chemotherapy and less than 14% respond to hormone therapy.
Patients between the ages of 31 and 75 who participated in the study lived an average of 23 months before the cancer progressed.
Professor Kristian Helin, Chief Executive Officer of ICR, said:
“Scientists have been working for decades to develop treatments that can effectively target cancers caused by KRAS.
“Early trials have shown that this treatment is very effective for this group of patients, and it’s great that Phase 2 trials have already begun.”
Dr. Susana Banergie, also an ICR consultant and research leader in the Royal Marsden Gynecology Unit, said: Cancer treatment.. “
The researchers said the combination therapy was effective in patients who had already been given MEK inhibitors prior to the study.
MEK inhibitors are drugs that can shrink the tumor but tend to stop functioning as the tumor becomes resistant to treatment.
Dr. Banerjee said:
“We are very much looking forward to this becoming the standard treatment for women with low-grade serous ovarian cancer.”
The results were presented at the 2021 European Society for Medical Oncology.
Additional report by Press Association
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