Health
Gut bacterial community found to be less diverse in people with irritable bowel syndrome
According to a Korean research team, people with irritable bowel syndrome (IBS) have less diversity of gut bacteria than healthy people. We believe this is the first analysis to find a clear link. This research microbiology spectruman open access journal of the American Society for Microbiology.
Typically, “more than 10,000 species of microorganisms live in the human gut,” says lead author Jung Ok Shim, MD, Ph.D., professor of pediatrics, pediatric gastroenterology, hepatology, and nutrition at Korea University School of Medicine. said. Soul. Disruption of the human gut microbiome can lead to IBS. IBS usually causes bloating, diarrhea, and stomach pains and cramps.
Previous studies on gut microbiota in patients with IBS have been controversial with inconsistent results due to small sample sizes and the lack of consistent analytical methods used in these studies. combined their own dataset with 9 publicly available shared datasets containing 576 IBS patients and 487 healthy controls and analyzed with a ‘uniform data processing and analysis method’.
The researchers found that the gut bacterial communities of IBS patients were less diverse than those of healthy people, Dr. Shim said. Furthermore, the abundance of 21 bacterial species differed between IBS patients and healthy controls. However, due to the small sample size, it was not statistically significant in the pediatric cohort.
Researchers have demonstrated that a disturbed gut flora “is associated with irritable bowel syndrome, but this does not mean that the relationship is causal.” Functional studies are needed to prove whether the alterations contribute to the development of irritable bowel syndrome.”
IBS is a common disease, but its etiology remains unknown and no effective therapeutic strategies are yet available. “Based on an epidemiological study of patients with IBS, alterations in the intestinal flora have been proposed as one of the possible causes of IBS,” the researchers wrote. and may cause chronic, asymptomatic, mild intestinal wall inflammation sufficient to alter epithelial cell function.”
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Journal reference:
Kim, GH, and others. (2023) Enterobacterial disorders in irritable bowel syndrome: a case-control study and cross-cohort analysis using published data sets. microbiology spectrum. doi.org/10.1128/spectrum.02125-22.
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