Health
Coronavirus antivirals are promising in hamsters and enter human testing
Antiviral drug Treatment that causes the virus COVID-19 (new coronavirus infection) According to the National Institutes of Health (NIH), it is promising in animal testing and is participating in human clinical trials.
According to NIH, the drug MK-4482 lowers viral levels and reduces lung disease damage to hamsters treated for infections. release.. Treatment works by preventing the replication of the virus and is effective when the drug is given 12 hours before or 12 hours after infection.Announced by researchers at the National Institute of Allergy and Infectious Diseases Survey results It is published in the Nature Communications journal.
Pfizer studying coronavirus oral antiviral therapy
“MK-4482 significantly reduces the pulmonary load and pathology of the virus when administered either 12 hours before SARS-CoV-2 infection or 12 hours after infection, but for shedding from the upper respiratory tract. It doesn’t affect you, “reads the study. “These findings support the potential of MK-4482 as an orally administered drug for high-risk exposure and possibly therapeutic use in humans.”
The study included three groups of hamsters. “Pre-infection treatment group; post-infection treatment group” and control group. In the treatment group, scientists administered the drug every 12 hours for 3 days. Finally, both groups of treated animals were found to have “significantly fewer lung lesions” and a 100-fold reduction in lung infectious virus compared to the untreated control group. ..
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The team has another antiviral drug, RemdesivirHas been given urgent FDA approval, but the treatment can only be given intravenously, “making it difficult to apply to the control of high-risk exposure,” the study authors write.
“These data indicate that MK-4482 treatment may reduce high-risk exposure to SARS-CoV-2 and established SARS-CoV-2 infection alone or perhaps in combination with other agents. It suggests that it may be used to treat “from NIH.
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