Connect with us


Team discovers key player in the spread of pancreatic cancer

Team discovers key player in the spread of pancreatic cancer


Researchers have identified a protein linked to pancreatic cancer metastasis.

Pancreatic cancer is the third leading cause of cancer-related deaths in the United States, and only 12% of patients survive five years after being diagnosed. Severe pancreatic cancer is associated with metastasis, and it is this spread of secondary tumors that usually results in death, but little is known about the molecular mechanisms causing metastasis.

In a new study in Advanced scienceResearchers from the University of California, Davis, show that abnormal expression of the Engrailed-1 (EN1) protein promotes pancreatic cancer progression and metastasis in vitro and in mouse models.

The team also found that elevated EN1 was associated with severe metastatic pancreatic cancer in human patients, suggesting that EN1 could be a good target for pancreatic cancer therapies.

“We identified a new epigenetic factor that may contribute to metastasis in pancreatic cancer, which is one of the most difficult cancers to treat,” says Chang-Il Hwang, assistant professor in the Department of Microbiology and Molecular Genetics at the UC Davis and lead author. paper. “A better understanding of these mechanisms would allow us to identify potential targets and improve patient survival. »

Metastasis is an important part of pancreatic cancer progression, but researchers have not been able to identify the genetic mutations that cause it. For this reason, Hwang believed that non-genetic factors, such as epigenetic changes or altered protein production, might be at play. His team previously identified several protein transcription factors that control the production of other proteins that are elevated in pancreatic cancers that have metastasized compared to primary tumors.

One of these proteins, EN1, is essential for neuronal survival during development and is generally not produced in adult pancreatic cells. EN1 has been shown to promote aggressive forms of breast cancer and is also associated with poor prognosis in other cancers, including glioblastoma and adenoid cystic carcinoma of the salivary glands, but its role in Pancreatic cancer had not been previously described.

The researchers tested whether inhibiting EN1 or increasing its expression impacted the growth and survival of pancreatic cancer “organoids,” three-dimensional clumps of tissue grown in the lab. They found that without EN1, pancreatic cancer cells were less likely to survive and divide, but adding extra EN1 increased tumor survival. Additionally, when researchers genetically engineered mouse pancreatic cancer cell lines so that they produced more EN1 than usual, the cells exhibited increased rates of invasion and cell migration, key features of metastases.

“It is very clear that EN1 is a very important factor behind the aggressiveness of pancreatic cancer,” says first author Jihao (Reno) Xu, a doctoral student in the Biochemistry, Molecular, Cellular and Developmental Biology graduate group. . “When we take tumor cells and make them overexpress EN1, they become more metastatic and aggressive, and when we kill them, they become less metastatic.”

By analyzing publicly available patient databases, the researchers also showed that EN1 is important for the prognosis of human pancreatic cancer. They found that EN1 levels were elevated in a subgroup of patients with advanced pancreatic cancer and that patients with elevated EN1 tended to have a poorer prognosis.

“Patients with high levels of EN1 have a shorter survival time, suggesting that this contributes to the aggressiveness of pancreatic cancer,” says Hwang.

Now, Hwang, Xu and their colleagues are working on ways to translate their findings to the clinic by testing different ways to target EN1. They also plan to continue studying other non-genetic factors that may contribute to the progression of pancreatic cancer.

“Ultimately, we want to identify new therapeutic strategies to combat this disease,” says Xu.

Other authors on the paper are from UC Davis, Yonsei University, Cold Spring Harbor Laboratory, Cornell University and the University of Nebraska Medical Center.

Support for the work came from the pilot grant from the UC Davis Comprehensive Cancer Center and the National Institutes of Health.

Source: University of California, Davis




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]