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WHO updates influenza treatment guidelines, including recommendations for viruses with pandemic potential
WHO has updated its guidelines for the care of flu patients. The guidelines are designed primarily for health care providers treating patients with influenza virus infection, and will serve as a reference resource for policymakers and others in efforts to prepare for an outbreak and pandemic.
Influenza is a viral disease. Seasonal flu is common in all parts of the world. It is estimated that there are approximately one billion cases of seasonal influenza annually, including 3-5 million cases of severe respiratory illness. An estimated 290,000-650,000 deaths each year are caused by seasonal influenza-related respiratory illness, in addition to deaths related to other influenza-related complications.
In addition to seasonal influenza viruses, animal influenza viruses – most commonly avian and swine influenza viruses – can occasionally infect humans. They can cause illnesses ranging from mild conjunctivitis to severe pneumonia and even death. Current animal influenza viruses have not demonstrated the ability to transmit from person to person, but they pose a pandemic threat for the future.
These guidelines make recommendations on the use of antiviral drugs and other treatments such as steroids to regulate the immune system. This update applies to patients with seasonal influenza viruses, potential pandemic influenza viruses, and novel influenza A viruses known to cause severe illness in infected humans.
A guideline development group composed of content experts, clinicians, patients, ethicists, and methodologists analyzed available data and produced these recommendations following standards for reliable guideline development using the Grades of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
The recommendations are part of the WHO's influenza response, which includes the work of the Global Influenza Surveillance and Response System (GISRS) and the Pandemic Influenza Preparedness (PIP) framework, which addresses gaps in access to effective medical therapies and other tools.
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