Health
Researchers elucidate cellular mechanisms that promote the initiation of mammary gland development
A research group at the University of Helsinki used biotissue imaging for the first time to visualize the appearance of the mammary glands.
Despite years of interest, the cellular mechanisms that drive the onset of mammary gland development remain elusive for decades, primarily due to technical limitations in the study of dynamic cellular behavior in living tissues. did. Recent advances in microscopy and the availability of various mouse models have allowed Marja Mikkola’s research group at the HiLIFE Institute for Biotechnology, University of Helsinki, to tackle this problem. This is the first time biotissue imaging has been used to visualize the appearance of the mammary gland.
The mammary gland is the organ that defines the class of mammals, but surprisingly little is known about how its development begins.In their recent study published in Journal of Cell BiologyUsing time-lapse imaging, Marja Mikkola’s research group showed that mammary gland bud growth is promoted primarily by cell migration to buds. In contrast, increased cell size and proliferation contribute to this process, but the role of these mechanisms remains minor.
Interestingly, mammary gland cells, unlike most other skin derivatives such as hair follicles and tooth buds, do not divide for several days, indicating that this may be a unique feature of early mammary development. I will. But I still don’t know why this happens. “
Ewelina Trela, graduate student, lead author of research
Mammary gland buds use a previously unexplained invagination mechanism
Tissue invagination, or tissue folding into the underlying stroma, is the basic mechanism that occurs to produce the structure of many organs. In the same work, the authors explain a new mechanism of organizational invasion.
“Using a confocal fluorescence microscope, we found thin, elongated epidermal keratinocytes that surround the mammary gland buds like edges. Their appearance and disappearance coincide with the invagination process, and these cells, called ring cells, It suggests that it may be functionally important, “said Senior Researcher Marja Mikkola. ..
Next, the Mikkola group, in collaboration with HiLIFE and the Sara Wickström group at the University of Helsinki School of Medicine, established live imaging of developing mammary buds and confirmed that ring cells move circumferentially around the mammary buds. Did.
The study also revealed that ring cells exert contractile forces via the actomyosin network via non-muscle myosin IIA (NMIIA). In NMIIA-deficient mice, ring cell function was impaired and mammary gland bud shape was impaired. Whether other developing organs utilize similar cellular mechanisms for invagination remains an open question.
Source:
Journal reference:
Leash, E. , et al. (2021) Cellular influx and contractile actomyosin force promote mammary gland bud growth and invagination. Journal of Cell Biology. doi.org/10.1083/jcb.202008062..
..
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
Pictures Credit
to request, modification Contact us at Here or [email protected]
 |
 |
 |
