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Higher genetic risk for early-onset cancers among minority families-ScienceDaily

Higher genetic risk for early-onset cancers among minority families-ScienceDaily

 


The increased risk of cancer due to the genetic predisposition of first-degree and second-degree relatives has long been established, but was previously studied only in Caucasian or European populations.

Now, the new research published in eLife Early-onset cancer among Latin-American and African-American families with solid tumors, and Asian / Pacific American families with blood-based cancers, compared to non-Latin white families in California Was first shown to have a significantly higher genetic risk.

“Family cancer clustering, a catastrophic diagnosis of multiple early-onset cancers within the same family, usually indicates a genetic cause. Interestingly, family cancer clustering was previously white or It was only investigated at the population level from Europe, “said Dr. Joseph Wiemels, a research author who is a member of the Cancer Epidemiology Program at the USC Norris Comprehensive Cancer Center and a professor of preventive medicine at the USC Keck School of Medicine. I will. “This study examined the clustering of cancer cases in a non-white population of young California families over the last three decades and compared it to the white population for the first time. It turns out that family-based cancer clustering occurs. More often among minorities. “

Researchers used the California population-based health registry to assess the relative risk of cancer among parents, siblings, and children of patients diagnosed with cancer by age 26. Between 1989 and 2015, 29,632 patients with early-onset cancer were identified and 62,863 healthy families. Overall, they found that mothers and siblings of these cancer patients had a higher relative risk of early-onset cancer. However, when we examined the role of race and ethnicity in genetic predisposition, patients with solid tumors were at increased risk of familial cancer in Latin and non-Latin black mothers and siblings. It turned out to be significantly higher than the Caucasian family of the descent. Asian / Pacific Islanders had an increased familial risk of blood-based cancers compared to non-Latin Caucasians.

This study shows that further scrutiny of familial cancer clustering in minority populations is needed. This information may help healthcare providers and genetic counselors provide more accurately based care and advice, especially in multi-ethnic groups residing in Los Angeles County.

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material Provided by USC Keck School of Medicine.. Original written by Hinde RKast. Note: The content can be edited in style and length.

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