Health
There is a plausible reason for men to have a short lifespan, which all depends on DNA
Wellington-Men are known to tend to be shorter-lived than women, but new studies done on sheep have shown that hormones may be the cause.
The study, led by researchers at the University of Otago in New Zealand, shows that removal of androgen hormones in sheep slows DNA aging and promotes the feminine characteristics of DNA and the chemical tagging of DNA known as DNA methylation. I did.
Androgens are a group of hormones that play a role in male characteristics and reproductive activity. It is usually thought of as a male hormone, but the female body also naturally produces small amounts of androgens.
“Both farmers and scientists have long known that removing androgens by castration extends lifespan compared to intact hormones, but we examined DNA to see if aging was slow. This is the first time for me, “said lead author Victoria. Sugrue, a PhD student in Varsity.
In this study, published in the journal eLife, the team first generated an “epigenetic clock” from a large number of sheep to measure DNA aging.
Next, when we examined the epigenetic clocks of castrated and intact men, we found that the “tick rate” was different. In other words, the longevity of castrated sheep, the “whether” that farmers refer to, is reflected in their DNA.
The findings provide a new way to understand the mechanism of accelerated male aging. The team found that the pattern of DNA aging in sheep was very different between males and females. Despite being male, the cast rate (whether or not) had very feminine characteristics at certain DNA sites.
“Interestingly, the sites most affected by castration also bind to human androgen receptors at a much faster rate than accidentally expected. This allows castration, androgens, and There is a clear link between gender differences in DNA aging, “said Tim Hoa, senior instructor in the Department of Androgens in Otago.
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Sources 2/ https://www.iol.co.za/lifestyle/health/theres-now-a-plausible-reason-why-men-have-a-shorter-lifespan-and-its-all-down-to-dna-3abe72e6-be85-5bfb-8e2e-4ab2ddd7da83 The mention sources can contact us to remove/changing this article |
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