Cartilage from the nose used to treat knee osteoarthritis in two people

NS Alice Klein

Implants made from nasal cartilage are used to repair the knee joints of two people with severe osteoarthritis. Larger clinical trials are currently being planned to see if this treatment can help millions of people with knee osteoarthritis worldwide.

Osteoarthritis of the knee It occurs when the cartilage in the knee joint gradually wears, leading to pain, stiffness, and difficulty walking. It is common in older people, but some young people can also develop it.

The only way to treat this condition is to replace the knee with a metal or plastic prosthesis.But these are Prosthodontics The joints are also worn and can lead to more surgery.

Ivan Martin The University of Basel, Switzerland, and his colleagues wondered if damaged knee cartilage could be replaced with healthy cartilage taken from the nose.

“The main target advantage is the effective regeneration of cartilage, as opposed to replacement by foreign bodies,” he says.

After successful experiments in mice and sheep, researchers tested this in severe knee osteoarthritis in a 34-year-old man and a 36-year-old woman.

First, they removed a small amount of cartilage from each person’s septum (the structure that separates the nostrils) and grew it in a dish to make a thin, flat sheet. The surgeon then inserted these cartilage grafts into the injured knee joints of men and women.

MRI scans showed that the nasal cartilage was well integrated into the joints. Eight months after the procedure, both were reported to have significantly less pain, improved knee function, and improved quality of life. Both were able to avoid traditional knee arthroplasty.

“The two cases treated can only provide anecdotal evidence, so larger clinical trials are now essential to test efficacy,” says Martin.

His team has just received approval from the Swiss medical regulator to test the approach with another 15 people with knee osteoarthritis. If that goes well, 64 people will start a larger study.

Journal reference: Scientific translation medicine, DOI: 10.1126 / scitm.aaz4499

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