Health
The $ 3 Million Breakthrough Prize is presented to Lahoya scientists fighting neuropathy
Scripps Research’s biochemist, who points out possible ways to prevent major diseases of the heart and nervous system, received the $ 3 million Breakthrough Prize, the largest economic award in science.
Jeffrey Kelly was among the nine who won the Breakthrough Prize on Thursday for doing everything from creating better methods for sequencing DNA to developing more accurate tests of the basic laws of nature. Is one of them.
The $ 3 million prize was introduced 10 years ago to honor the relatively recent advances in physics, science and mathematics, and is steadily gaining international fame.
Kelly, 62, won an award for her research on proteins, the “components of life.”
He focuses primarily on transthyretin. Transthyretin, like other proteins, folds into an origami-like shape during development. The protein may not be in the correct shape or retain its folds. It destroys cells and tissues and produces masses that can kill people.
Aggregation is best known for creating amyloid plaques associated with Alzheimer’s disease. However, such plaques are associated with about 40 diseases of the nervous system and heart.
Kelly has developed a molecule that stabilizes transthyretin. He then helped transform the molecule into Tafamidis. Tafamidis is a drug that slows the progression of the disease, says Scripps Research. His research also showed that such aggregation plays a greater role in neurodegeneration than scientists once thought.
Kelly told Union Tribune, “It’s very simple in a way, but it took a long time to achieve this so that we could get a very safe and effective molecule to slow the progression of neurodegenerative diseases. ”
In some cases, the entire $ 3 million Breakthrough Prize will be awarded to one recipient for work in a particular area. In other cases, money is split among multiple people who have tackled the same breakthrough. Kelly has received the full $ 3 million.
When he heard about the award, “I thought I was being mischievous,” Kelly said. “But the source was so reliable that it quickly turned into” Oh My God. “
“Sure, some (money) is spent on philanthropy, because it’s a very important part of my life and makes scientific careers available to people.”
Kelly is up to date in a long line of major award-winning Scripps Research scientists. The Lahoya-based laboratory has four Nobel laureates. And the journal Nature ranked Scripps as the world’s most innovative private life sciences institute in 2017.
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