Health
MIS-C solves heart problems quickly
Longitudinal analysis showed that heart problems due to pediatric multisystem inflammatory syndrome (MIS-C) associated with COVID-19 infection usually resolved within 3 months.
Of the 42 children with MIS-C who showed evidence of myocardial damage, 81% lost left atrial systole during acute illness and dropped to 52% in the days immediately following vasoactive treatment, said the child. Hospital Anirban Banerjee, MD reported. Philadelphia, and colleagues.
The systole of the left atrium normalized in all patients after 3-4 months, the researchers said. Journal of the American Heart Association..
Six patients had elevated levels of brain natriuretic peptide, 13 had elevated levels of troponin, and 23 had elevated levels of both. There were no deaths or unexpected cardiac events.
The survey results are Guidelines Children with MIS-C state that they can gradually return to physical activity such as competitive sports within three months.
along Previous researchAll deformation parameters, including left ventricular (LV) global longitudinal strain, peak left ventricular strain, longitudinal initial diastolic strain rate, and right ventricular free wall strain, recovered within the first week and then 3 months. It was completely normalized.
The median time to normalization of both overall longitudinal strain and left atrial strain was 6 days. The median time to normalization of left ventricular ejection fraction was 8 days, and 9 days for right ventricular free wall strain.
“This rapid recovery of left ventricular dilatation is a hallmark of MIS-C,” writes Banerjee and colleagues. “Many other causes of acute heart failure in children result in slower recovery of diastolic function over months or years.”
For example, in Kawasaki disease Very similar to MIS-C, Diastolic heart failure Up to 1 year..Diastolic dysfunction may persist in other cases of non-COVID viral myocarditis over 1 year..
MIS-C can develop weeks after COVID-19 infection, Most common for children 6-10 years..Children can present at heart, brain, Skin and eyes problem. Adolescents vaccinated with the Pfizer / BioNTech vaccine were protected from severe MIS-C. In a recent CDC study..
Banerjee et al. Analyzed data from 60 age-matched controls with 60 MIS-C patients. Patients with MIS-C were admitted to either Philadelphia Children’s Hospital or St. Peter’s University Hospital in New Brunswick, NJ from April 2020 to January 2021. All were positive for PCR or antigen COVID test.
The average age of MIS-C patients was 10 years, 60% were boys and 48% were blacks. The median length of stay was 6 days. Patients were treated with intravenous immunoglobulin (90%) and / or systemic steroids (92%).
Patients with a history of cardiac dysfunction, congenital heart disease, exposure to cardiotoxic substances, and chronic lung disease, as well as patients treated with extracorporeal membrane oxygenation were excluded.
Two-dimensional echocardiography, speckle-tracking echocardiography, clinical, and cardiovascular MRI data were obtained from patients with MIS-C. Two-dimensional echocardiography data were obtained at four time points: the acute phase of the disease, the subacute phase of the days immediately following treatment, one month, and three or four months. Only 25 patients were successfully followed up in 3 or 4 months.
Banerjee and the team pointed out that MIS-C is a “newly reported disease” and may be the result of a lack of standardization for follow-up care, and the follow-up rate for this study is high. I admitted that it was low. They also noted that their study considered only short-term results of 3-4 months and did not measure potential long-term effects.
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