Health
Studies show that Covid-19 can “explode” infected cells
Infected cells COVID-19 The virus can “explode” and has been shown by researchers to contribute to the development of severe illness.
Scientists in the United States and the United Kingdom have examined blood samples of people infected with Covid, and about 6% of monocytes (the immune cells that patrol the body for foreign invaders) are a type of cell death associated with inflammation. I discovered that I was receiving (called pyroptosis). , Infected with a virus.
A small portion of macrophages, another type of immune cell that swallows and destroys foreign cell debris, also became inflamed after being infected with Sars-CoV-2.
For the two cell types, the virus is thought to have activated what is called the inflammasome. The inflammasome is a large molecule that triggers a cascade of inflammatory responses that can lead to cell death.
Studies have long suggested that severe Covid’s disease is caused by inflammation, leading to damage to the lungs and other organs.
Previous studies have shown that the immune system of people with Covid releases a protein called cytokines that fights infections, which can effectively turn the body on by attacking healthy tissues. increase. These “cytokine storms” are associated with serious illness.
The collaboration with Boston Children’s Hospital by scientists at the Royal Free Hospital in London suggests that pyroptosis is also involved in the exacerbation of serious illness.
“Inflammation and cell death are both important contributors to severe Covid, and our studies show that pyroptosis is often the cause,” said Dr. Gautam Mehta, a hepatologist at Royal Free Hospital. rice field. The Mail on Sunday.
Dr. Meta said that the pyroptosis pathway functions as the body’s “alarm system.” “Detecting intracellular bacterial or viral particles leads to a” explosion “of the cell and the release of pro-inflammatory contents.
“This has the advantage of eliminating the infection, but it can result in severe inflammation. Pyroptosis literally means” burning “cell death. “
Scientists believe that infected immune cells could be potential targets for drug development and hope to design new therapies to prevent people infected with Covid from becoming seriously ill. doing.
“Currently, our Covid treatment targets the virus itself, so this is a big discovery,” said Dr. Mehta.
“If we can target the processes that cause serious illness, we will be able to develop effective treatments for patients who do not respond to the vaccine.”
Another study, which has not yet been peer-reviewed, showed how Sars-CoV-2 invades immune cells-for scientists given that these cells do not have many ACE2 receptors. The point of previous confusion is the entry that the virus uses to acquire.
Scientists at Yale University School of Medicine have discovered that the virus, with the help of antibodies, can invade human cells via another surface protein known as the Fcγ receptor.
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Sources 2/ https://www.independent.co.uk/news/science/covid-19-cells-explode-inflammation-latest-b2080775.html The mention sources can contact us to remove/changing this article |
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