Health
Population-sized studies highlight the continued risk of COVID-19 in some cancer patients despite vaccination-ScienceDaily
In a study jointly led by Oxford University, Birmingham University, Southern Pton University, and the UK Health and Security Agency (UKHSA) and published today in Lancet Oncology by the British Coronavirus Cancer Assessment Project, COVID-19 vaccination is most cancerous. It turned out to be effective for. For patients, the level of protection against COVID-19 infection, hospitalization, and death provided by the vaccine is lower than in the general population, and the effectiveness of the vaccine declines more rapidly.
Dr. Leonard Lee of the Department of Oncology, Oxford University, who led the study, said: However, no studies have investigated the efficacy and decline of vaccines in cancer patients at the population level. We conducted the largest assessment of COVID-19 in a hands-on healthcare system for cancer patients around the world.
This study analyzed 377,194 people with active or recent cancer who received two COVID-19 vaccines and underwent SARS-CoV-2 PCR testing in the United Kingdom.1..Number of breakthrough COVID-19 infections and COVID-19-related hospitalizations and deaths2 This cohort of cancer patients was compared to an active or recent cancer-free control population.
Overall vaccine efficacy against COVID-19 infection in the general population after two doses of COVID-19 vaccine during the study was 69.8%, while overall vaccine efficacy was slightly lower in the cancer cohort. (65.5%). This shows that COVID-19 vaccination is effective for most cancer patients. However, the effectiveness of the vaccine declines more rapidly in cancer patients. Three to six months after the second vaccination, vaccine efficacy decreased by almost one-third from 61.4% in the general population to 47.0% in the cancer cohort.
The vaccine provides better protection against COVID-19-related hospitalizations (83.3%) and deaths (93.4%) than breakthrough infections in the cancer cohort, but this protection is also 3-6 after the second vaccination. It weakened in months.
Looking at the differences between people with different types of cancer, the vaccine is the least effective and the fastest to decline in people with lymphoma and leukemia.
The type of treatment that cancer patients receive also affects both the overall efficacy and decline of the vaccine. In cancer patients treated with chemotherapy or radiation therapy in the last 12 months, the effectiveness of the vaccine is lower than in cancer patients who did not receive these treatments or were treated more than a year ago, 3-6. It declines in months.
Professor Peter Johnson, a professor of oncology at the University of Southampton, commented: This highlights the importance of vaccination booster programs and rapid access to COVID-19 treatment for people receiving cancer treatment.
Helen Rowntree, Director of Research, Services and Engagement at Blood Cancer UK, said: .. We know how important vaccines are to people with blood cancer. Importantly, this study shows that people with blood cancer who are eligible for five vaccinations have a faster weakening of their immunity.
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material Provided by Oxford University.. Note: Content can be edited in style and length.
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