COVID-19 rebound reported after Pfizer’s Pilpax robid, says CDC

What you need to know about Pfizer and Merck’s COVID treatments

US health regulators have approved two tablets developed by Pfizer and Merck for COVID-19 that Americans can take at home.

The US Centers for Disease Control and Prevention issued an alert on Tuesday to keep healthcare providers up-to-date about the potential for COVID-19 to relapse or “rebound” after using Paxlovid.

Paxlovid is Pfizer’s powerful COVID-19 pill, making it a reliable choice for treating COVID-19 due to its convenience at home and impressive results for avoiding serious illness. increase. It has been shown to reduce the risk of hospitalization or death from COVID-19 by up to 90%.

CDC said on Tuesday COVID-19 rebound has been reported to occur 2-8 days after initial recovery from the virus. “Rebound” can be characterized by recurrence of COVID-19 symptoms and / or re-positive after being already negative.

The CDC does not state how many cases of rebound have been reported.

According to the CDC, the first person treated with a pill that experienced a COVID rebound was a mild illness.

“Currently, there is no evidence that Paxlovid or other anti-SARS-CoV-2 therapy requires additional treatment if COVID-19 rebound is suspected,” said the CDC.

In addition, the CDC emphasized that Paxlovid’s 5-day pill regimen is still recommended for early treatment of mild to moderate COVID in people at high risk of severe illness.

Paxlovid approved in December It is based on a study in which 1,000 adults took the drug. It is OK based on the performance of the COVID for the delta variant and may not be very strong for the current Omicron variant.

The US government has spent more than $ 10 billion to buy enough pills to treat 20 million people.

Related: The United States recognizes the risk of “disastrous” COVID supply and distributes without additional funding

Who should take Pax Rovid?

The CDC states that the drug reduces the risk of hospitalization and death for patients at risk of disease progression or severe illness.

Those who are eligible to take Paxlovid:

• COVID test positive
• Have mild to moderate illness
• Have one or more Risk factors for progression to serious illness
• No current hospitalization required at the time of treatment
• No evidence of severe renal or liver dysfunction

Paxlovid should be taken as soon as possible within 5 days of the onset of symptoms. The regimen consists of three tablets taken twice daily for 5 days.

Photo illustration of Pfizer COVID-19 drug Pax Rovid’s box (Photo courtesy of Europa Press / C.Lujan. Getty Images via pool)

Related: COVID-19 Vaccine for Children Under 5 Years: Pfizer says 3 small doses provide strong protection

Who is susceptible to COVID recurrence?

The CDC said a short-term recurrence of COVID symptoms could be part of the natural history of the virus in some people, regardless of vaccination status or Paxlovid use.

Both the FDA and Pfizer point out that 1% to 2% of people in Pfizer’s first study saw virus levels recover after 10 days. The proportion was about the same among those taking drugs and dummy tablets. “Therefore, it is unknown at this time that this is related to drug treatment.” FDA said..

No possible commonalities were reported among those who experienced a recurrence.

What is the risk of COVID recurrence?

Earlier this month, the Food and Drug Administration advised people with COVID rebounds for a second Paxrovid treatment because there is little risk of serious illness or hospitalization for relapsed patients. CDC agrees He states that patient monitoring is the best course of action during the COVID rebound.

The CDC said the potential infection during COVID rebound was explained, but researchers still elucidate whether the potential for infection during rebound differs from the potential for infection during the initial infection. ing.

People with COVID rebounds should follow CDC recommendations for quarantine..

If you are taking Paxlovid and may have a COVID-19 rebound, Report a case to Pfizer via an online tool..

This story was reported by Detroit. The Associated Press contributed.

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