Irritable Bowel Syndrome: Rectal Carbon Monoxide Bubbles Relieve Mouse Symptoms

To Grace Wade

Carbon monoxide foam delivered via the rectum can reduce inflammation in mice and rats and accelerate tissue recovery.

Colorless and odorless gases are most widely known as dangerous poisons and can lead to coma, convulsions and ultimately death at blood levels above 50%.

But it’s not necessarily harmful. Our bodies actually produce small quantities on a daily basis, and about 20 years ago, Leo Ottervine At Harvard Medical School, I noticed that when I got sick, my production increased.

Since then, several studies, primarily in animals, have shown that low doses of carbon monoxide help treat conditions such as cardiovascular disease and cancer, primarily by reducing inflammation. ..

However, the challenge is to develop a safe and effective way to manage it. Dosing and safe storage can be problematic for delivery methods such as inhalation and infusion.

Now, whipping gas into bubbles may work.

“We really wanted to try an out-of-box, ready-to-use approach,” he says. James Burn With co-authors of a new study with Ottervine at the University of Iowa Healthcare Giovanni Traverso At the Massachusetts Institute of Technology. “So we looked at molecular gastronomy and what they did in terms of pushing up the physical boundaries of food,” he says.

Researchers have placed ingredients commonly found in processed foods, such as xanthan gum, in pressurized containers containing carbon monoxide. The gas was then trapped inside these materials by whipping at high speed. The resulting formulation looks like just a little bit of milk in a whisk. All materials are food grade and the concentration of carbon monoxide is very low, so there is no risk of handling the material, says Burn.

Next, insert the foam into the rectum of approximately 40 mice and rats exhibiting any of the three symptoms of irritable bowel syndrome, radiation-induced bowel disorder, or liver failure associated with acetaminophen overdose. Did. Over all three, treated rodents had significantly reduced inflammation and tissue damage compared to those given control foam or not treated at all.

The benefits seen in the liver show that when carbon monoxide is released from the foam, it can enter the bloodstream and access other organs, says Otterbein. This means that foam has the potential to treat a wide range of conditions, including cardiovascular disease, kidney disease, and lung disease.

“I don’t know if there is another foam used to supply the therapeutic gas,” Traverso says. “This opens up a whole new way of thinking about treatment.”

Journal reference: Scientific translation medicine, DOI: 10.1126 /scitranslmed.abl4135

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