Paxlovid helps people with mild COVID-19 symptoms

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• Researchers say Paxrovid and other antiviral drugs help avoid serious illness even in people with mild COVID-19 symptoms.
• However, they warned that scientists need to be constantly aware of new treatments as the new coronavirus is constantly changing.
• They also state that anyone taking certain other medications or supplements should consult their doctor before taking Paxrovid.

Pax Robin teeth effective An antiviral drug taken within the first few days of onset of symptoms to prevent hospitalization and death from COVID-19.

In the United States, currently only people with certain medical conditions at high risk of developing severe COVID-19 are eligible to receive this drug.

Now, New research Expanding eligibility to include everyone with COVID-19 suggests that it could benefit everyone.

Canadian researchers have studied 41 trials of more than 18,000 non-severe COVID-19 patients. They reported that taking Paxlovid was likely to reduce 46 hospitalizations per 1,000 cases compared to those who received standard of care or placebo.

Researchers also have antiviral drugs Molnupiravir It can also be somewhat beneficial, as it reduces 16 hospitalizations per 1,000 patients.

“This review addresses an important gap in the evidence, as antiviral drugs may be most useful for non-severe illnesses.” Tyler PitreThe author of the lead study and a physician residing at McMaster University in Ontario, press release..

Dr. Jimmy JohannesPulmonologists and critical care specialists at the Memorial Care Long Beach Medical Center in California said the findings did not surprise him.

“These findings are in line with my expectations based on the critical clinical trials of both Paxlovid and molnupiravir,” he told Healthline.

“I think we need to be more aware of the availability of these antiviral treatments between the general public and healthcare providers,” he continued. “It is also necessary to recognize that these treatments are most effective in the early stages of COVID-19 infection. Therefore, early testing to confirm COVID-19 infection is important. In addition, COVID- For those at risk of becoming infected with 19, I think the medical system needs to find an efficient way to facilitate access to Paxlovid early on. “

However, meta-analysis has its limits and experts are paying attention. The rate of mutation of COVID-19 means that it is unclear whether the results that apply to one variant of the virus (mainly last year’s Delta variant in this case) are valid for another variant.

“Meta-analysis is useful when cost and logistical constraints prevent long-term studies of large groups of patients to look for rare events,” he said. Dr. David Cutler, A family doctor at the Providence St. John’s Health Center in California. “But it also causes many causes of error, and the findings must be interpreted with caution.”

and Commentary In the Canadian Medical Association Journal, where the study was published, reviewers noted much the same and emphasized the crucial importance of vaccination status as a primary prophylaxis against severe COVID-19.

“”[Paxlovid] It may be less effective in a real environment than the findings of the relevant network meta-analysis suggest, “they write. “Recent observational studies examining the effectiveness of [Paxlovid] It was concluded that it was effective in reducing severe COVID-19 among vaccinated patients who were infected with Omicron and had no evidence of previous infection. “

But they said another story said that “only vaccination was more effective.” [Paxlovid] And its effectiveness [Paxlovid] There was no change depending on the vaccination situation. “

They also mentioned that Paxlovid maker Pfizer has recently shut down. Examination of vaccinated individuals Due to low hospitalization or mortality in the standard risk population.

Experts say that another reason doctors should be aware of when prescribing Paxrovid is the high number of interactions with other medications and supplements.

“The general availability of Paxrovid needs to be limited due to potentially serious interactions with many commonly used drugs,” Cutler said. “This means that patients need to confirm their use of herbs, vitamins, supplements and prescription drugs before safely prescribing Paxlovid.”

However, experts say antivirals will continue to be part of the weapons that fight our COVID, regardless of whether Paxlovid’s availability will be expanded in the United States.

“I don’t know if antiviral treatment will help control and contain COVID-19, but living with COVID-19, treating COVID-19, and especially in people at highest risk of hospitalization. I think they will be important to prevent serious illness and hospitalization, “said Johannes.

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