Daily Gazette
Get the latest Harvard news by signing up for our daily email.
Health
In mouse model, scientists develop cancer vaccine that kills brain tumors – Harvard Gazette
the scientist Brigham and Women’s Hospital It uses a new method to turn cancer cells into powerful anticancer drugs.
From Khalid Shah’s lab, BWH researchers at Harvard University have developed new cell therapy approaches to eliminate established tumors, induce long-term immunity, and train the immune system to prevent cancer recurrence. made it possible to prevent The team tested a dual-acting, cancer-killing vaccine in an advanced mouse model of the deadly glioblastoma brain tumor, with promising results.The findings are published in Science Translational Medicine.
“Our team pursued a simple idea: to take cancer cells and transform them into cancer killers and vaccines,” said corresponding author, Stem Cell and Translational Immunotherapy Center and Vice Chair of Research neurosurgeryy at Brigham University and Faculty of Harvard Medical School and Harvard Stem Cell Institute. “We are using genetic engineering to repurpose cancer cells to develop therapies that kill tumor cells, stimulate the immune system to destroy primary tumors, and prevent cancer.”
Cancer vaccines are an area of active research in many laboratories, but the approach taken by Shah and his colleagues is unique. Instead of using inactivated tumor cells, the team reuses live tumor cells with abnormal characteristics. Like a homing pigeon returning to its roost, live tumor cells travel long distances in the brain to return to the location of their fellow tumor cells. Taking advantage of this unique property, Shah’s team manipulated living tumor cells using the gene-editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agents. In addition, engineered tumor cells are designed to express factors that enable the immune system to easily discover, tag and remember, priming the immune system for long-term anti-tumor responses. .
The team has developed repurposed, CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTCs) in a variety of mouse strains, including those that yield human-derived bone marrow, liver, and thymocytes that mimic the human immune microenvironment. ) was tested. Shah’s team also incorporated her two-layer safety switch into cancer cells. When this switch is activated, he will eradicate ThTC if necessary. This dual-acting cell therapy is safe, applicable, and effective in these models, suggesting a roadmap to therapy. Although further testing and development is needed, Shah’s team specifically chose this model and used human cells to smooth the way for translating their findings into the patient setting.
“Throughout everything we do at the center, we never lose sight of our patients, even if they are highly technical,” says Shah. “Our goal is to take innovative yet translatable approaches that will ultimately allow us to develop therapeutic cancer-killing vaccines that will have a lasting impact on medicine.” Shah and colleagues note that this therapeutic strategy is applicable to a broader range of solid tumors, requiring further investigation of its application.
Disclosure: Shah is an equity owner and member of the board of directors of AMASA Therapeutics, a company developing stem cell-based therapies for cancer.
This work was supported by the National Institutes of Health (Grant R01-NS121096).
|
Sources 2/ https://news.harvard.edu/gazette/story/2023/01/in-mouse-model-scientists-develop-cancer-vaccine-that-kills-brain-tumors/ The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
