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Burden of cervical cancer remains high for women over age 65

Burden of cervical cancer remains high for women over age 65

 


January 17, 2023

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Among California patients with cervical cancer, women aged 65 and older had a higher disease burden than younger women, researchers report.

“Our findings highlight the need to better understand how current screening guidelines fail in women over the age of 65. Julian JP Cooley MS, A senior statistician at the University of California, Davis Health, Sacramento, said in a press release:

Data obtained from Cooley JJP et al. Cancer Epidemiol Biomarker 2023;doi:10.1158/1055-9965.EPI-22-0793.

Data obtained from Cooley JJP et al. cancer epidemiol biomarker2023; doi:10.1158/1055-9965.EPI-22-0793.

ACOG, U.S. Preventive Services Task Force The American Cancer Society recommends that women complete cervical cancer screening when they reach age 65 and have had sufficient negative screening within the past decade. Fifty-eight percent of women aged 64 to 66 in our database did not meet screening criteria.”

Cooley et al. identified 12,442 patients aged 21 and older who were diagnosed with their first primary cervical cancer between 2009 and 2018 in the California Cancer Registry. Researchers analyzed sociodemographic and clinical characteristics, including cancer stage and subtype, comorbidities, neighborhood socioeconomic status, and health status. Insurance, urbanity, marital status, race/ethnicity, age and year of diagnosis – by age group.

In total, 2,171 (17.4%) women were older 65 years of age or older.

The proportion of women in each age group diagnosed with stage II or later cervical cancer (referred to as late stage) increased with age across the 75- to 79-year age group. Diagnosis rates ranged from 60.2% to 70.6%, compared with 33.5% to 58.7% among young women.

The 5-year relative survival decreased with age. Survival rates for young women ranged from 89.3% to 93.6% for her, and from 51.6% to 81.5% for women over 65 years of age. Her 5-year relative survival rates for women with end-stage cervical cancer ranged from 23.2% to 39.1% for women aged 65 years and older and from 41.5% to 51.5% for younger women. The 5-year survival rate was lowest for women aged 80 years and older.

Among women ≥65 years of age, older age at diagnosis was associated with late diagnosis (OR = 1.02; 95% CI by age, 1.01–1.04) with two or more comorbidities versus no comorbidities (OR = 1.59; 95% CI, 1.21-2.08) and squamous cell carcinoma (OR = 1.38; 95% CI, 1.1-1.74) or other subtypes (OR = 2.52; 95% CI, 1.68-3.79) vs . Adenocarcinoma.

Hispanic women were less likely to have a late diagnosis compared with non-Hispanic white women (OR = 0.76; 95% CI, 0.6–0.97). No other sociodemographic factors were associated with late diagnosis.

“We need to focus on identifying past screening histories and follow-up care failures in older women,” Cooley said in a release. , non-invasive testing approaches must be utilized for women who need to catch up on cervical cancer screening.”

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