COVID-19 infection may increase patients’ risk of developing diabetes

According to a new study published in , the diagnosis rate of new-onset cardiometabolic disease was higher in the three months after COVID-19 infection compared to the three months before COVID-19 infection. JAMA network opened. Patients who were not vaccinated also had a higher risk of developing diabetes.

“Adjusted multivariate models significantly increased the risk of diagnosis of new-onset diabetes (compared to benchmarks) after and before COVID-19 infection,” the study authors wrote. “Although persistent inflammation contributing to insulin resistance has been proposed as a pathway, the mechanisms contributing to diabetes risk after infection remain unclear.”

Early in the COVID-19 pandemic, previous studies found that some patients had an increased risk of new cardiometabolic diseases such as diabetes, hypertension and hyperlipidemia after infection.

Although the latest Omicron subtype appeared to be of low pathogenicity, there are sufficient data on the risk of developing cardiometabolic disease after COVID-19 infection and the effect of vaccination status on the risk of developing cardiometabolic disease. There was no

Investigators conducted a current study to address these questions and identified 23,709 patients who had been infected with COVID-19 at least once. The patient was treated at Cedars-Sinai Health System in Los Angeles from March 2020 until he June 2022.

Using code from International Classification of Diseases, 9th revision and International Statistical Classification of Diseases and Related Health Problems, Tenth Revisioninvestigators investigated newly reported cardiometabolic diagnoses before or after a patient’s first COVID-19 infection.

Comparing the results of cardiometabolic diagnostics to a COVID-19-unrelated benchmark diagnostic, researchers found that 90 days post-infection compared to pre-infection, new-onset cardiometabolic and benchmark disease We observed a high diagnostic rate.

The likelihood of developing new diabetes was significantly higher after COVID-19 than before infection. Among cardiometabolic diseases, the risk of developing diabetes was highest, followed by hypertension, benchmark diagnosis, and hyperlipidemia.

The researchers also linked vaccination status with the risk of new-onset diabetes. The data showed that the odds ratio for diabetes after infection was 1.78 in unvaccinated individuals and 1.07 in vaccinated individuals. However, “the duration of the interaction between vaccination status and diabetes diagnosis was not statistically significant,” the study authors wrote in their paper.

Researchers who analyzed age, gender, or pre-existing cardiovascular risk factors found no evidence to prove that these factors increase the risk of cardiometabolic disease after COVID-19 infection. The researchers were unable to associate age, sex, or the timing of her first COVID-19 infection with the risk of new-onset cardiometabolic diagnoses before or after infection.

This study was limited because it used diagnostic coding, did not consider confounding factors, and did not have sufficient sample size or statistical power to test multiple interactions.

“Additional research is needed to understand the cardiometabolic sequelae of COVID-19 and whether COVID-19 vaccination reduces the risk of cardiometabolic disease,” the study authors wrote in their paper. increase.

reference

Kwan A, Ebinger J, Botting P, et al. Association between COVID-19 vaccination and diabetes risk after COVID-19 infection. JAMA network opened. 2023 doi:10.1001/jamanetworkopen.2022.55965. Accessed 16 February 2023.