New hydrogel stem cell therapy may repair damaged brain tissue

A new ‘hybrid’ hydrogel allowed researchers to safely deliver stem cells to the site of brain injury in mice.

Researchers at Australia’s University of Melbourne and Australian National University have developed a new ‘hybrid’ hydrogel that can be safely delivered stem cell At the site of brain injury in mice.

Hydrogels are aqueous gels that can be used to deliver substances into the body and can be used to promote effective growth of new cells.

was announced in Nature Communications, a proof-of-concept breakthrough solves a major challenge that has faced stem cell researchers since the 1980s — when stem cells are inserted into a damaged area, they become the cells needed to create new tissue. It’s about keeping stem cells alive long enough so that they can evolve. body.

The hydrogel supplies both the stem cells and the oxygen they need to keep them alive during the infusion process, ensuring that they evolve into the type of cells needed to create new tissue to repair damage. increase. Researchers believe this advance could aid in stem cell therapy in many other parts of the body beyond the brain and central nervous system.

Professor David Nisbet says: That’s why you need a temporary blood supply to support your cells until your blood system is repaired. This patented hydrogel provides that.

“There are very few medications that can treat stroke and other conditions such as stroke. Parkinson’s disease And they have little effect. Currently, there are no treatments that can reverse these conditions. “

Professor Colin Jackson says this breakthrough will be of interest to researchers and clinicians around the world and will likely lead to many innovative medical treatments.

“Although proof-of-concept is currently being demonstrated in the mouse brain, this work provides a general basis for developing injectable nanomaterials for a variety of applications, including cell transplantation, gene and drug delivery, and three-dimensional structures. represents a viable strategy. in vitro disease model and Organ-on-a-chip technologysaid Professor Jackson.

Mouse brain tissue 28 days after injection of hydrogels containing myoglobin shows greater amounts of transplanted healthy brain tissue compared to injections of hydrogels without myoglobin. [Credit: Yi Wang].

After more than five years of research, the team added a synthetic protein based on myoglobin (a naturally occurring protein present in high concentrations in the heart muscle of sperm whales and horses) to the hydrogel to ensure the persistence necessary for stem cell survival. have been found to provide significant oxygen release. Through the delivery process, it develops into the types of cells needed to repair brain tissue.

Professor Clare Parrish of the University of Melbourne, who conducted a mouse study, said the results were achieved with damaged brain tissue, raising the possibility of growing new tissue for future human treatments.

“We found that hydrogels incorporating myoglobin and stem cells repaired damaged brain tissue. Analysis 28 days after delivery of the hydrogels showed healthy brain function compared to hydrogels without myoglobin. “We found that the survival and growth of the new stem cells that are required for physiotherapy are greatly enhanced,” said Professor Parrish.

“We observe that new tissue is stimulated in a manner similar to healthy brain tissue, and are the first of the advantages of including oxygen delivery within hydrogels to achieve long-term survival and integration of stem cell transplantation.” I have provided proof.”

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