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Air pollution may increase dementia risk

Air pollution may increase dementia risk

 


April 11, 2023

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Disclosure: This research was supported by Biogen and NIH. Weisskopf reports joining Biogen’s Healthy Climate, Healthy Lives Advisory Board. Wilker reports payroll support from Alexion and Moderna Tx. All other authors did not report relevant financial disclosures.


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Important points:

  • Particulate matter, nitrogen dioxide, and nitrogen oxides may be risk factors for dementia.
  • Findings provide evidence for particulate matter regulation.

Air pollution may be a risk factor for dementia, according to the results of a meta-analysis published in . BMJMore.

Elissa H. Wilker, ScD, Associate professor of medicine in the School of Epidemiology and Environmental Health at the Harvard TH Chan School of Public Health in Boston and colleagues longitudinally followed adults to assess the association between dementia and U.S. Environmental Protection Agency-designated air pollutants and traffic. We searched databases for studies that Tainted proxy.



Air pollution, such as fine particulate matter, can increase the risk of dementia.Image: Adobe Stock
Air pollution, such as fine particulate matter, can increase the risk of dementia. Image: Adobe Stock

A total of 51 studies were included, most of which (n = 38) were evaluated. Particulate Matter (PM2.5)All studies were published in the last decade, with most (n = 33) published in 2020 or later. Most were conducted in North America (n = 25).

Of these studies, 16 studies met the inclusion criteria for the meta-analysis, of which 7 were from North America, 6 from Europe and 1 from Hong Kong.

Of the 14 studies that assessed PM2.5there was a trend towards increased risk of dementia for every 2 µg/m3 PM’s2.5 (Overall HR = 1.04; 95% CI, 0.99–1.09).

Nitrogen dioxide (NO2), five evaluated nitrogen oxides (NOx), and four evaluated ozone (Ox).3). In the analysis dementia risk per 10 μg/m3 no2 (HR = 1.02; 95% CI, 0.98-1.06) and per 10 μg/m3 noX (HR = 1.05; 95% CI, 0.98-1.13). There was no relationship between O.3 and dementia.

“This is a big step forward in providing actionable data to regulators and clinicians in terms of understanding the state of the literature on this very important health topic.” Dr. Mark G. Weiskopf, PhD, Cecil K., lead author and Philip Drinker Professor of Environmental Epidemiology and Physiology at the Harvard TH Chan School of Public Health, said in a press release: “The results can be used by organizations like the Environmental Protection Agency that are currently looking to tighten PM limits.2.5 exposure. Our findings support the public health importance of such measures. ”

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