Rockefeller University » Periodontal disease may be at the root of arthritis flare-ups

Soft tissue blood vessels between joints during flares of rheumatoid arthritis.

It’s a well-documented medical mystery: patients with periodontal disease are less likely to respond to rheumatoid arthritis treatment. may help explain this relevance. was announced in Science Translational Medicinesuggests that when damaged gums are ruptured, bacteria in the mouth can seep into the bloodstream, activating an immune response that ultimately targets the body’s own proteins to trigger arthritis flare-ups. .

“Oral bacterial invasion and repeated triggering of the immune response associated with rheumatoid arthritis can be difficult to treat,” said Dana Orange, a clinical research professor in the Robert B. Darnell lab at The Rockefeller University. says. “When a doctor encounters an arthritis patient who does not respond to treatment, it is worth making sure that the underlying periodontal disease is not overlooked, which is fully treatable.”

Darnell Laboratories When they were following a small group of arthritis patients for several years, collecting weekly blood samples and looking for changes in gene expression to help explain why painful flare-ups occurred, they discovered We noticed a surprising trend. Two patients with moderate to severe periodontal disease had repeated episodes of oral bacteria in their bloodstream even when they were not receiving dental care.

Orange knew that people with rheumatoid arthritis commonly have autoantibodies in their bloodstream (rheumatoid arthritis is an autoimmune disease in which antibodies attack the body’s own proteins and peptides). Autoantibodies often target proteins that show signs of citrullination. This is the process by which her one amino acid in the protein is converted to another amino acid.

After further testing, the researchers found that the oral bacteria detected in the blood were also citrullinated in the oral cavity, similar to proteins targeted by arthritic autoantibodies. They next demonstrated that the same autoantibodies that attack the body’s citrullinated proteins are activated in response to citrullinated bacteria.

This result may explain why arthritis treatments fail in patients with periodontal disease. Treating arthritis without it is like trying to get water out of a ship without plugging the leak first.

“Gum disease is completely cured. Rheumatoid arthritis can be much more difficult to treat,” says Orange. This level of oral bacteria in the blood does not cause obvious symptoms, so the patient was unaware that this was happening, but rheumatoid arthritis. provokes inflammatory and autoantibody responses that are highly relevant to

These findings also demonstrate the importance of conducting longitudinal studies to better understand chronic diseases. Current research would not have been possible without the original initiative pioneered by Orange and Darnell several years ago. It allows arthritis sufferers to collect their own blood samples at home using a finger prick kit and have the samples mailed to Rockefeller each week.The lab now has several years of data to help track What happens in the blood just before arthritis recurs?

“Without weekly blood samples for at least a year, we wouldn’t have been able to figure out what was going on before the patient showed symptoms of a flare-up,” says Orange. “Our study reveals a plausible mechanism explaining why rheumatoid arthritis patients with periodontal disease respond poorly to treatment, which is very difficult to grasp without long-term monitoring. That’s it.”

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos