Health
Oral levodopa/carbidopa pumps may improve on/off time in Parkinson’s disease
C. Warren Olanow, MD, FRCPC
Administration of levodopa/carbidopa (LD/CD) via an intraoral pump resulted in significant improvement in dyskinesia-free on and off times in Parkinson’s disease (PD) patients.
The findings of this study are presented by C. Warren Olanow, MD, FRCPC, 2023 American Neurological Association Annual Meeting, April 22-27, Boston, MA. Henry P. and his Olanow, Professor Georgette Goldschmidt and Honorary President of the Department of Neurology and Professor of Neuroscience at Mount Sinai College of Medicine in New York City, described the device DopaFuse (Synagile). It attaches to a non-invasive oral retainer worn by the patient. Her LD/CD in liquid is pumped directly into saliva for 5-6 hours continuously from the pump and swallowed, allowing the patient to avoid invasive infusion pumps and other less than ideal administrations. increase.
A non-randomised, open-label study involving 16 participants evaluated the variability in plasma levodopa concentrations between theDopaFuse pump and standard intermittent levodopa. Effects on motor function, including OFF time, ON time without severe dyskinesias, and ON time without dyskinesias. So is the safety and tolerance of the DopaFuse system.
read more: Syn-One test reports high sensitivity and specificity across multiple synucleinopathies
Participants were evaluated over a two-week period. On day 1, participants received the usual dose of standard LD/CD. On day 2, the participant received only consecutive LD/CDs in her DopaFuse. And on day 3, the participant received her standard LD/CD in the morning, followed by her LD/CD continuously via her DopaFuse pump. rice field. The participant remained on her Day 3 dosing regimen from her Day 4 through her Day 14 and was re-evaluated on Day 15.
Between days 1 and 3, the variability index assessing plasma levodopa concentrations improved significantly, with a variability index of 2.15 on day 1, 1.49 on day 2, and 1.03 on day 3 (P. <.001). Compared to baseline, his off-time and on-time without severe dyskinesias were significantly improved on his third day and maintained through day 15 (3.23 hours vs 1.63 hours vs 1.51; P. <.001 and 12.77 hours vs 14.36 hours vs 14.49 hours. P. = .001, respectively). Dyskinesia-free ON time was also improved (8.82 hours vs 9.76 hours vs 10.9 hours; P. <.02) similar to UPDRS part II score (11.5 on day 1 vs 9.4 on day 15; P. = .016). In the subset of participants with more than 2 hours off time at baseline, off time was also statistically significantly improved on his 3rd day and his 15th day (4.28 hours vs 1.19 hours vs 1.25 hours ; P. <.001).
Overall, the treatment was safe and well tolerated, with no dropouts, serious treatment-related side effects (AEs), clinically significant AEs, or deaths. Treatment-emergent adverse events included buccal lesions, vomiting, nausea, headache, venipuncture hematoma, and orthostatic hypotension, all of which resolved within 1 to 5 days.
Describing how participants used retainer pumps, Olanow said: [disease] better controlled. ”
“If this turns out to be what we want, it will allow us to deliver levodopa without the risk of subcutaneous lesions or the need for infusion pumps, without motor complications or surgical intervention,” Olanow concluded. I was.
Click here for more information on AAN 2023.
reference
Olanow CQ, McIntyre D, Matarazzo M, et al. Continuous delivery of levodopa/carbidopa using an intraoral DopaFuse system: a safety, tolerability, PK, and efficacy study. Announcement: AAN Annual Meeting. April 22-27, 2023. Boston, Massachusetts and Virtual.
|
Sources 2/ https://www.neurologylive.com/view/oral-levodopa-carbidopa-pump-improve-on-off-time-parkinson-disease The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
