Health
Proteins that have been studied for many years may help measure the severity of traumatic brain injury-health
Scientists at the Walter Reed Army Institute of Research (WRAIR) show that cathepsin B, a protein that has been heavily studied for brain development and function, can be used as a biomarker or an indicator of severity of traumatic brain injury. Recently demonstrated
Traumatic brain injury (TBI) or brain trauma results from a blow to the head and leads to life-altering brain confusion and a long-term chain of health. TBI, the leading cause of disability and death worldwide, can result from skull trauma such as gunshot wounds, falls, and car accidents. Athletes, seniors, children and military service are particularly vulnerable.
Biomarkers are of great interest to researchers because they can dramatically improve both the diagnosis and classification of TBI severity. In addition, they have the potential to validate treatment strategies by showing whether the drug reached their proposed goals and achieved therapeutic benefits.
In the Journal of Neurotrauma publication, researchers have shown increased levels of cathepsin B in areas of the brain that are impaired that are involved in the control of sensory, language, memory, and other important executive functions.
In healthy cells, cathepsin B plays a number of roles, including eliminating damaged cells, maintaining metabolic homeostasis, and breaking down improperly produced proteins. When cathepsin B levels are not tightly controlled, it is associated with inflammation and tissue death.
This publication reports the first results showing that cathepsin B can be used as a blood-based biomarker to identify TBI severity in various brain regions and cerebrospinal fluid.
“A biomarker test that accurately reflects the extent and severity of injury dramatically improves standard care, minimizes the need for resource-intensive diagnostics such as CT and MRI scans, and is more portable. The primary author,” Section Chief of Molecular Biology and Proteomics, within the Brain Trauma Neuroprotection Branch of WRAIR.
“This allows us to detect TBI early and accurately, even on the roadside after an accident, and most importantly on the battlefield, to guide medical decisions,” Boutte added.
Future studies are planned to further characterize the role of cathepsin B in TBI.
(This article has been published from the telegraph agency feed with no changes to the text. Only the headings have changed.)
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