Health
Vaccine Trial | Duke Health’s New Universal Influenza Vaccine Trial Uses mRNA Technology to Boost Protection
Duke Health is conducting trials of a new universal influenza vaccine that aims to use mRNA technology to boost protection against more strains.
“Just plug it in and you’re ready to go. That’s right. He is a PhD at the Duke Human Vaccine Institute and a principal investigator leading clinical trials.
according to CDCAt least 27 million people have been infected with the flu this season, including 290,000 hospitalizations and 19,000 deaths. Current vaccines are pre-formulated based on scientists’ predictions of which strains will be the most dominant, allowing manufacturers to produce vaccines.
“One of the big problems with influenza is the variability of the flu. Influenza strains can also change during the season through January and February,” Walter said.
The federal health agency states that vaccine efficacy ranges from 40% to 60% seasonally.
“We want to be able to develop vaccines that provide more cross-protection and flu vaccines,” says Walter.
The trial involved 50 adults aged 18 to 49, was planned before the pandemic, and the mRNA gained a lot of attention for use in Pfizer and Moderna’s novel coronavirus vaccines.
“We need better flu vaccine. The ones that offer better protection are the ones that allow us to respond more quickly in the event of problems like 2008 when there is a discrepancy between what is in vaccines and what is actually in circulation.” said former pediatrician Dr. Jeb Takeman. Called the prospect a “game changer,” they expressed concern that misinformation about mRNA could affect vaccination coverage.
The issue was personal to Teichmann, whose son Brent died of the flu in 2019 at the age of 29. Brent planned to get the vaccine, but he didn’t get it until he got it.
“I asked him to pick up the phone so I could hear the paramedics trying to resuscitate my son. They’re calling for multiple doses of epinephrine. When I close my eyes at night, I can still see the monitor. I hear a beeping sound.” Teichmann added that his son was otherwise healthy at the time of his death.
He is currently working with Families Fighting Flu, a non-profit advocacy group that promotes education, awareness and vaccination.
“This is what I do now. It’s my son’s legacy to talk about flu and vaccinations in general,” Teichmann said.
In the first phase of the trial, enrollees will be monitored for one year, and some of the participants will serve as controls for the current vaccine, administered at different dose levels. Researchers will study vaccine safety and immune responses, including how the vaccine persists if the virus mutates. Based on these results, it may be possible to extend coverage to other age groups.
FDA approves first home test that can detect both influenza and COVID-19
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