Health
Study finds weight loss pill Wegovy has significant additional benefits
Patients taking weight loss pill Wegobee for one year have reduced risk of heart disease, early evidence that Novo Nordisk’s best-selling obesity drug may also have a positive impact on cardiovascular health was suggested by
People followed in the study said their 10-year risk of cardiovascular disease was reduced by 18% Andres AcostaAssociate Professor of Medicine mayo clinic. The researchers used standardized surveys of heart risk to evaluate about 100 people (mostly white women) who had taken Wegovy over her year in clinics across the United States.
Because the study was done in the real world, not in a clinical trial, there was no control group, so the researchers wondered whether the improvement was due to Wegobee, commonly known as semaglutide, or whether there were other factors. I couldn’t say for sure. play. But Acosta said in an interview that the results are a silver lining as doctors await the results of larger, more rigorous trials conducted by Novo.
The results “are an excellent sign that the ongoing Select trial on overall cardiovascular disease mortality is hopefully successful,” Acosta said in an interview. assigned name Go to Novo’s study. “But we have to wait for those studies.” He presented the findings at the conference. European Obesity Conference in Dublin.
The large trial, which is following 17,500 patients with a history of obesity and cardiovascular disease, is expected to have results this summer.
albeit much smaller mayo clinic The study was not randomized, and the authors said they observed positive effects on blood pressure, blood sugar, liver function, and reduced use of other drugs. Grace O’MalleyHe, who heads the Obesity Research and Care Group at the RCSI College of Medicine and Health Sciences in Ireland, was not involved in the trial.
uncontrolled vomiting
It is important to hear about “outcomes other than weight,” o’malley said, focusing on the frequency of side effects. “Access to obesity drugs for people with obesity-related complications should be protected and should not be used to attempt to change body size for cosmetic reasons.”
The Mayo Clinic team also looked at patients’ weight loss and side effects. About 300 patients followed by the group showed an average weight loss of about 13% of body weight, which mirrored the results observed in randomized clinical trials. About half experienced side effects, mainly nausea, diarrhea, abdominal pain, and constipation.
About 5% of Wegovy patients required hospitalization or emergency room visits for severe side effects, according to Acosta, a higher number than confirmed in clinical trials. He said the hospital visit was the result of a patient becoming dehydrated from uncontrolled nausea and vomiting, highlighting the need for doctors to closely monitor patients as weight-loss drugs become more widely prescribed. said it was a manifestation.
Real-world trials mirrored the limited supply experienced by obese patients. Acosta said doctors at the clinic prescribed the drug to about 1,000 people, but only about 300 started taking it. Shortages and lack of insurance coverage made it difficult for patients to obtain medicines.
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Sources 2/ https://fortune.com/well/2023/05/19/wegovy-diet-drug-heart-risk-dips/ The mention sources can contact us to remove/changing this article |
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