A study conducted at the Loma Linda University School of Health Sciences found that even small amounts of regular exercise in sedentary older adults could have a significant effect on slowing the aging process at the level of molecular gene expression. is suggested.
Using a recently developed measure of mRNA expression, researchers found that short, long periods of high-intensity exercise reduced biological age by nearly 3.6 years. This means that the study participants’ cells began to behave like cells in people 3.6 years younger.
“To our knowledge, this is the first time that exercise has been tested as an independent intervention using next-generation measures of biological age, and that even small amounts of exercise have health implications in sedentary older adults. A really tangible effect on the aging process,” said Dr. Trevor Roman, a lecturer at the United Graduate School of Health Professionals at Loma Linda University and lead author of the study.
The researchers used what is known as a transcriptome age predictor to study RNA molecules in the cells of 30 sedentary adults. Fifteen were placed in the exercise test group and 15 in the control group. Participants in the exercise group underwent an exercise protocol known as high-intensity interval training three times a week. The study lasted 4 weeks.
The researchers found that improved biological age was also associated with improved body composition, sleep quality, and lower rates of depression in test group participants.
“These results suggest that exercise influences age-related gene expression patterns, and that such effects may potentially contribute to the positive health and longevity effects associated with exercise.” ,” the authors say in a journal article.
This study adds to the existing evidence that exercise benefits overall health, especially in later life.
“We’ve all heard the story of a 65-year-old being hospitalized with heart disease, and we’ve probably all heard the story of a 65-year-old running a five-kilometer race. “There’s clearly something going on across society that’s changing the way people age, apart from just heredity,” Roman said.
The study’s researchers noted that future studies could include testing with larger sample sizes, more spaced transcriptome age measurements, and long-term follow-up measurements after the study ends. suggested there is.
This research was funded by Loma Linda University. Associated Medical Professional Graduate School.
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