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Obesity can permanently alter the brain’s response to nutrients

Obesity can permanently alter the brain’s response to nutrients

 


May 12, 2023 — A new study of how lean and obese people’s brains respond to nutrients explains why it’s hard for people to lose and maintain weight. may be

Yale University researchers found that the stomachs of 28 people considered lean (as defined by a body mass index) and 30 classified as obese had sugar, carbohydrates (glucose), fat (lipids), or water (lipids) in their stomachs. as a control) was directly injected, and the state of the stomach was observed. Brain activity by magnetic resonance imaging.

Bypassing the mouth focused on the gut-brain connection and showed how people would respond without tasting or smelling food, says lead author Mireille, professor of endocrinology at Yale University School of Medicine. Celery, M.D. said. CNN.

Imaging tests showed that lean or normal-weight people had lower brain activity and increased release of dopamine, a chemical that triggers feelings of “reward” from food. But people believed to be obese did not show decreased brain activity or release of dopamine, says a study published in 2006. natural metabolism.

Participants defined as obese were enrolled in a 12-week weight loss program. Those who had lost at least 10% body fat underwent repeat gastric infusions and brain imaging, and weight loss did not alter brain response.

“Nothing changed. The brain was still not recognizing fullness or satisfaction,” Celery told CNN. “Well, you might say that three months isn’t enough or you didn’t lose enough weight.

“But the findings may also explain why people lose weight so successfully that they regain it after a few years. The effects on the brain may not be reversible as much as we would like. ”

Sources

1/ https://Google.com/

2/ https://www.webmd.com/obesity/news/20230612/study-obesity-may-permanently-change-brain-response-to-nutrients

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