Health
How COVID-19 Doesn’t Work With Old Blood Diluents
Much of the effort to develop treatments and vaccines to combat COVID-19 has focused on spike proteins used by the criminal virus, SARS-CoV-2, to invade healthy cells. Scientists at the Rensselaer Polytechnic Institute believe that they have found a way to block the ability of spike proteins to infect cells. This includes 78 year old blood diluent.
The drug is heparin, which is widely used to treat and prevent blood clots. The RPI team has discovered that SARS-CoV-2 binds strongly to heparin, a potential “bait” as a way to neutralize the virus before it infects healthy cells. They reported locate (PDF) Journal Antiviral Research.
Researchers at RPI have made a discovery by examining SARS-CoV-2 gene sequence data and recognizing certain properties of spike proteins that are thought to be likely to bind heparin. They tested three drugs against viruses, including non-anticoagulants, and used computational modeling to define how they bind to pathogens.
By binding to SARS-CoV-2, anticoagulants trap the virus. It just decomposes,” said Dr. Jonathan Dordick, a professor of chemical and bioengineering at RPI, video..
The Dordick team was already working on ways to trap the virus when the COVID-19 pandemic began to spread. Researchers have developed a virus trap technology that uses fragments of DNA to mimic the latching site of human cells and published studies showing promising initial data for dengue, influenza A, and deer.
Looking for ways to convert virus trap technology to COVID-19, Dordick teamed with Dr. Robert Linhardt, a professor of chemistry and chemical biology at RPI, who is renowned for making synthetic heparin.
Some anticoagulants are already in use by doctors treating COVID-19. Demand for Bristol-Myers Squibb elixirs soared earlier this year. report The drug should be able to prevent stroke in critically ill patients.
RPI researchers have suggested using heparin as a temporary measure against COVID-19 until a vaccine is found. They suggested that the drug may be delivered in inhaled form to people exposed to COVID-19.
“This approach can be used as an early intervention to reduce infections in people who test positive but have not yet suffered from symptoms,” said lead author Linhart. statement.. “In the end, we need a vaccine, but there are many ways to fight the virus. As we saw with HIV, with the right treatment, we can control the disease until a vaccine is found. .”
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What Are The Main Benefits Of Comparing Car Insurance Quotes Online
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