Health
Dr Ricciuti on PD-L1 Expression and Long-Term Survival Outcomes With PD-L1 Inhibitors in Advanced NSCLC
Biagio Ricciuti, MD, thoracic medical oncologist, staff scientist II, Department of Medicine, Dana-Farber Cancer Institute, discusses the association between PD-L1 expression levels and long-term survival with anti–PD-L1 monotherapy in patients with advanced non–small cell lung cancer (NSCLC).
At the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer, Ricciuti presented 3-year outcomes and correlative analyses from 2 independent cohorts of patients with advanced NSCLC and a PD-L1 tumor proportion score (TPS) of 50% or greater who have previously received PD-1 inhibition.
Initial data from these analyses showed that patients with a very high PD-L1 expression level (TPS of 90%-100%) had better clinical outcomes with first-line pembrolizumab (Keytruda) vs those with a lower PD-L1 expression level (TPS of 50%-10%), Ricciuti details.However, there were no data with long-term outcomes in among patients with high PD-L1 expression levels (50-89%) vs very high (90% or greater) PD-L1 expression within this population, he notes.
Analysis of 3-year survival outcomes for patients treated with cemiplimab (Libtayo) in the phase 3 EMPOWER-Lung-1 trial (NCT03088540) revealed that those with high PD-L1 expression levels exhibited lower response rates and shorter median progression-free survival and overall survival compared with patients who have very high PD-L1 expression, Ricciuti reports.
Patients in the validation group who received pembrolizumab did not experience a significant difference in survival outcomes at the 3-year mark between low and high PD-L1 expression groups, Ricciuti adds.
Moreover, patients with very high PD-L1 TPS had a lower prevalence of STK11/SMARCA4 mutations and increased CD8-positive/PD-1–positive T cells, indicating a more favorable genomic and immunophenotypic profile.
These findings confirm that PD-1 monotherapy provides long-term survival benefit for patients with advanced NSCLC and very high PD-L1 expression. Long-term outcomes suggest that PD-1 monotherapy can be a reasonable treatment alternative for patients with very high PD-1 expression levels (90% to 100%) compared to chemo-immunotherapy, potentially sparing them from the added toxicity of chemotherapy, Ricciuti concludes.
|
Sources 2/ https://www.onclive.com/view/dr-ricciuti-on-pd-l1-expression-and-long-term-survival-outcomes-with-pd-l1-inhibitors-in-advanced-nsclc The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
