Health
Clinicians report first successful drug test for patient with life-threatening blood clotting disorder
A team led by researchers at Massachusetts General Hospital, a founding member of Massachusetts General Hospital, used a new drug to save the lives of patients with immune thrombotic thrombocytopenic purpura (iTTP). iTTP is immune thrombotic thrombocytopenic purpura, a rare disease characterized by uncontrolled clotting throughout its life. small blood vessels. This group describes the first clinical use of the drug for iTTP. New England Medical Journal.
“We have shown that this drug, a genetically engineered version of the missing enzyme in iTTP, can reverse the disease process in very critically ill patients,” said lead author Pavan K. Bendapudi, MD. said the doctor. He is a researcher in the Division of Hematology and Transfusion at Massachusetts General Hospital and an assistant professor at Harvard Medical School.
iTTP is caused by an autoimmune attack on an enzyme called ADAMTS13, which is responsible for cleaving large proteins involved in blood clotting. The current mainstay of treatment for this life-threatening blood disease is plasma exchange, which removes harmful autoantibodies and provides additional ADAMTS13. Although plasmapheresis induces a clinical response in most patients, it can restore, at best, only about half of normal ADAMTS13 activity. In contrast, a recombinant form of human ADAMTS13 (rADAMTS13) offers the potential to significantly increase ADAMTS13 delivery.
rADAMTS13 was recently approved for patients with congenital thrombotic thrombocytopenic purpura. Congenital thrombotic thrombocytopenic purpura occurs in patients with congenital thrombotic thrombocytopenic purpura. ADAMTS 13 gene. Although it is questionable whether rADAMTS13 is effective in iTTP given the presence of inhibitory anti-ADAMTS13 autoantibodies, Bendapudi et al. permission was obtained to use rADAMTS13 in dying patients. His iTTP is treatment-resistant.
“We found that rADAMTS13 rapidly reversed the disease process in this patient, despite the current wisdom that inhibitory autoantibodies to ADAMTS13 render the drug ineffective in this condition,” Bendapudi said. “We were the first doctors in the United States to use her rADAMTS13 to treat her iTTP, and in this case it helped save the young mother's life.”
Bendapudi noted that the injected rADAMTS13 overwhelmed the patients' inhibitory autoantibodies and reversed the thrombotic effects of iTTP. This effect was observed immediately after administration of rADAMTS13 after daily plasma exchange failed to induce remission.
“We believe that rADAMTS13 has the potential to replace the current standard of care in acute iTTP. Larger, well-designed trials are needed to evaluate this potential,” Bendapudi said. .
A phase 2b randomized clinical trial of rADAMTS13 in iTTP was recently initiated.
|
Sources 2/ https://www.sciencedaily.com/releases/2024/05/240517164139.htm The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
