Researchers aim to streamline cancer detection with liquid biopsy

A team of researchers at the University of Rochester are reporting a new way to detect cancer cells using a “liquid biopsy” designed to be easier, faster and more informative than current methods.

What is a liquid biopsy? It is a non-invasive test that uses blood, urine, and other body fluids as a medium to find cancer cells and other molecules released by tumors. Liquid biopsies can detect or screen for cancer and monitor disease progression and the body's response to cancer treatment.

Dr. Jim McGrath

Dr. James McGrathWilliam R. Kenan Jr. Professor, UR Professor of Biomedical Engineering; Wilmot Cancer Institute The scientific team led a collaborative effort to develop a tool to collect cellular material (genes and proteins) called extracellular vesicles (EVs). Selecting and analyzing EVs can provide valuable information about diseases within the body.

Despite the excitement and long-standing potential of this field, questions center on how best to analyze the “bioactive cargo” within EVs and develop accurate biopsy tools.

The researchers explain that current methods are expensive, complex, and too limiting because scientists cannot analyze multiple biomarkers simultaneously.

The UR image-based tool takes a digital approach and early studies have proven its sensitivity in classifying hundreds of thousands of EVs. The researchers say they can detect cancer at an earlier, more curable stage and unravel the function of EVs, which play a role in cancer spread and the immune system's response to disease.

their job is reported in a magazine smalla publication in nanoscience and nanotechnology, of which biomedical engineering student Samuel Walker is the first author.

Additionally, Jonathan Flax, MD, research assistant professor of urology; Dr. Scott GerberWilmot Associate Professor of Surgery and cancer researcher, are collaborating on the discovery of EV-based biomarkers to detect whether immunotherapy is effective against cancer.

Future plans include using new tools in clinical research to guide the results of treatment-based clinical trials, McGrath said.

Read the UR news release.

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