Why does SARS-CoV-2 have different effects on patients? Researchers find clues

Researchers at McMaster University and the University of Waterloo are collaborating to find out how the SARS-CoV-2 virus infects the lungs. They are trying to be accepted truth about viruses.

Previously, scientists have determined that SARS-CoV-2 entry into cells occurs through a cell surface receptor known as ACE2. However, McMaster Waterloo team found that the ACE2 receptor is at very low levels in human lung tissue.

Jeremy Hirota, Co-Principal Scientist at St. Institute, said: Joe Hamilton and McMaster’s Associate Professor of Medicine.

“I was surprised that the basic characterization of candidate receptors for human lung tissue has not yet been done in a systematic way in modern technology.”

“Finding such low levels of ACE2 in lung tissue has important implications for what we think about the virus.” Andrew Doxey co-leads Professor of Biology at the University of Waterloo. Said. “ACE2 is not a complete story, and may be more related to other tissues such as the vascular system.”

A paper on their findings recently .. Their findings have been independently confirmed by other researchers ..

Currently, the team is using nasal swabs collected for clinical diagnosis of COVID-19 to investigate another additional route of infection and the response of various patients to the infection. These samples provide the opportunity to determine which genes are expressed by the patient’s cells and correlate this information with the onset of the patient’s disease.

Ongoing research will better identify and treat patients at risk of developing serious complications and provide hospitals with predictive capabilities.

“It’s clear that some people are more responsive to the same SARS-CoV-2 virus than others. Mr. Hirota, McMaster and Canada Research Chair for Respiratory Mucosal Immunology, said The difference in response suggests that individual patients have their own unique characteristics, which greatly influence the severity of COVID-19 disease.

“It is the pulmonary immune system that differs between COVID-19 patients, and understanding which patients have useful and harmful lung immune systems will help physicians manage most aggressively in high-risk patients. I may be able to help.”

Researchers correlate positive and negative COVID-19 cases with clinical outcomes and ultimately use this data to generate predictive algorithms related to morbidity and mortality. The goal is to use this predictive information to optimize healthcare delivery.

The research has received grants from the Ontario Government’s Ontario COVID-19 Rapid Research Fund, Roche Canada’s COVID-19 Innovation Challenge, and FastGrants.org, operated by The Thistledown Foundation of Canada.

“We believe we have the opportunity to use this information to develop diagnostic devices, so we are looking for additional partners to work with us to advance this research,” said Hirota.

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