Health
Omega-3 Fatty acids and vitamin D. Biological aging of elderly people is slow
Many people want to delay or stop the aging process. Previous clinical studies show that a decrease in calories can slow down human aging processes. Ingesting vitamin D or omega-3 fatty acids shows promising results due to slow animal aging. However, it was unknown whether these measures work for humans.
Previously tested in the DO-Health study led by Heike Bischoff-Ferrari is also related to the delay in the aging process. These indicated that vitamin D, omega -3 fatty acids, and regular physical activities reduce the risk of infection and fall, preventing cancer and early frail.
These results have urged the direct effects of these three treatments to biological aging processes in Swiss -resistant participants. “
Bishov Ferrari, Professor of the Geriatrics and Elderly Medicine University of Zurich
Biological and age measurement
One of the scientific approaches to enable biological aging is the use of epigenatic watches. They record the chemical modifications of DNA molecules known as methylation, and thus we quantitizes the aging of biological aging and aging. DO-Health research was sensitive to how this molecular biological measurement reacts to target treatment.
Investigating Omega 3,/or vitamin D and/or biological strength training in cooperation with Steve Horvath, a senior researcher of Altos Labs Cambridge (UK), led by Heike Bischoff-Ferrari. I did. 777 aging over 70 years old. Eight different treatments were tested during three years of research. The subject took 2,000 international units (IU) vitamin D and/or 1 grams of omega-3 fatty acids (algae) every day. /I conducted a 30 -minute strength training at home three times a week.
Biological age decelerated
When researchers analyze blood samples, they take omega -3 fatty acids, regardless of the gender, age, or body mass index of the subject, for up to 4 months of biological aging over several epigenetic watches. I found out that it would be late. The combination of omega-3, vitamin D, and muscle strength training has been further effective, according to one of the four epigenatic watches used.
“This result has expanded the previous discoveries from DO-Health research, which combines these three factors. These three factors have reduced the risk of cancer, preventing early frail for three years, and biology. Bischoff-Ferrari has a big impact on the aging process. Each measured value functions through the various mechanisms that complement each other and combines, and the overall effect is enhanced according to the research author.
Do-Health as a verification platform
At the same time, the research team is paying attention to the limits of research. “There is no generally accepted gold standard to measure biological age,” says Bishov Ferrari. “But we have analyzed the best epigenatic watches today. This reflects the cutting edge.” Bischoff-Ferrari is Global Health Span to further promote the clinical application of biological clocks. Along with the major international researchers of the Extension Consortium, we plan to use DO-Health and other global intervention studies as a new biomarker verification platform for aging.
Researchers also point out that samples are not represented by the world's 70 -year -olds, because they are only composed of Switzerland participants. In the next step, they plan to expand their analysis to all difficult participants, including people in Germany, France, Austria and Portugal.
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Journal Reference:
Bischoff-Ferrari, HA, et al。 (2025). Vitamin D, Omega 3, and exercise individuals and additional properties, and exercises on DNA methylation clocks for the elderly from the DO-Health test. Aging of nature。 doi.org/10.1038/s43587-024-00793-Y。
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