Health
Marine bacteria hold promise for colorectal cancer treatment
photobacterial narrow It was found to be an effective vector for bacterial cancer immunotherapy in preclinical studies.
researchers Japan Advanced Institute of Science and Technology (Ishikawa Prefecture) completed an initial bacterial immunotherapy study using: photobacterial narrow (P. Angstam). This bacterium, which has antitumor properties, was tested in a mouse model of colorectal cancer as an alternative to existing immunotherapies. This innovative research demonstrated the ability of this bacterium to selectively target tumor cells, raising hopes for more effective cancer treatments.
Although new cancer treatments are constantly being developed, many face the significant challenge of not targeting only tumor cells, thereby risking inducing toxicity in surrounding healthy tissues and vital organs. Immunotherapy has shown promising results but is often hampered by high cost, side effects, and limited efficacy in some cancer types. These limitations highlight the need for innovative, cost-effective, and highly selective treatment options.
The use of bacteria as vectors for immunotherapy has been studied in conjunction with genetically engineered strains. A research team led by Eijiro Miyako screened multiple marine bacterial strains in a colorectal mouse model to evaluate their ability to directly kill tumor cells while activating the immune system. Because the bacterial strains were not genetically modified and were grown at room temperature, this approach is practical and scalable.
Of the several strains analyzed, one strain stood out from the others. P.Narrow demonstrated excellent tumor inhibition with high selectivity and little colonization in healthy tissues and organs. Biocompatibility testing of treated mice P.Narrow showed long-term survival. This efficacy was found to be driven by direct tumor lysis and strong immune system activation via T cells, B cells, neutrophils, and proinflammatory cytokines such as TNF-α and IFN-γ.
P.Narrow They also demonstrated an excellent safety profile and durable response, with all tumor-free mice completely rejecting secondary tumor growth when cancer cells were readministered 120 days after initial treatment. The research team also noted that this bacterial strain showed antitumor effects in a drug-resistant triple-negative breast cancer model, suggesting it may have broader applications.
The results of this study serve as a proof of concept for bacterial immunotherapy for the treatment of solid tumors using non-genetically engineered bacterial strains. In the future, it is possible to conduct further research into the mechanisms by which immune activation occurs and expand the cancer models tested. Furthermore, researchers can now aim to assess long-term immunological memory induced by immunological memory. P.Narrow With further development, the team hopes to: P.Narrow This could pave the way for a new therapeutic paradigm of biocompatible bacterial therapy that does not require genetically modified organisms.
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Sources 2/ https://www.oncology-central.com/marine-bacteria-shows-promising-in-tackling-colorectal-cancer/ The mention sources can contact us to remove/changing this article |
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