Health
New findings explain how the brain prepares the body for food
Our brains prepare our bodies for the incoming meal before we even take the first bite. For example, the smell of food simmering on the stove can prompt your brain to send a signal to your pancreas, which releases insulin into your bloodstream. new natural metabolism Research has revealed how a key group of neurons helps mediate this process.
The hypothalamus is the part of the brain that regulates appetite through different groups of neurons, including proopiomelanocortin (POMC) neurons, which control satiety. Recent studies have found that these neurons are activated not only during eating, but also by the anticipation of food. However, it remains unclear what molecular factors drive this process.
Now, researchers have discovered that this anticipatory activation is driven by pockets of glycogen within POMC neurons. Glycogen is the main way we store energy, and the body breaks it down into glucose when it needs fuel. Studying the neural circuits that cause feelings of hunger and satiety could help scientists better understand how to treat metabolic diseases such as obesity, researchers say.
“Obesity is a dysregulation of feeding circuits at the brain level, making it a disease of the brain rather than a disease of the body,” he says. Dr. Mark Schneeberger Payneassistant professor of cellular and molecular physiology, is co-principal investigator on this study. “Understanding how these neurons function in physiology is an important first step to being able to appropriately treat obesity.”
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