Health
A heavily ignored “housekeeping” gene is involved in seizures
In the cell, molecules known as transfer RNAs or “tRNAs” are important, but unattractive, in facilitating the genetic translation process from the DNA code to a functional protein.
TRNAs are abundant because they play a very important role in the “housekeeping” of this translation. Mammalian cells have hundreds of tRNA genes and have ample backup copies in case something goes wrong. However, tRNAs are so abundant that they have been overlooked in looking for the root of the disease process.
Scientists studying tRNA in mice in San Diego, California say that mutations in the tRNA gene called n-Tr20, which is only expressed in the brain, disrupts the entire cell landscape and chain reactions alter brain function. And acted.
The new study is explained in the journal on August 26 Neuron..
Postdoctoral researcher Murid Kapur, who works in the lab of professor Susan Ackermann, the author of the study, said she and her colleagues found that n-Tr20 is a subtlety of excitatory and inhibitory neurotransmission in the brain. He says he has found a role in balance. This imbalance is associated with many neurological disorders such as epilepsy and autism spectrum disorders.
While tRNAs have been commonly overlooked in the search for genetic causes of disease, recent whole-genome sequencing projects have revealed many variations in tRNA sequences in the human population. Our study suggests that tRNA variants have great potential to contribute to disease outcome and phenotypic variability. “
Mridu Kapur, Study First Author
The researchers found that deficiency in n-Tr20, a member of the tRNA family of five genes, made mice resistant to seizures. They say that their initial interest in this region came from the idea that tRNA mutations could affect other gene mutations, but the result is that tRNA mutations affect other mutations. In addition to confirming their speculation that it is possible, these mutations alone show that they may alter the brain function.
“You can imagine it’s like a seesaw. Pressing either can cause problems,” says Howard Hughes Medical Institute, a member of the Neurobiology Department of Cellular and Molecular Medicine. The member, Ackermann, said. “Balancing these two opposing forces is essential for normal function. Any shift can cause neurological disorders. In the field of autism spectrum disorders, excitatory/inhibitory nerves. It is widely accepted that the transmission imbalance is actually recognized.”
Ackerman says one of the reasons tRNAs have been overlooked in disease research is that researchers are generally focusing on mutations in their own genes. Members of large families, such as n-Tr20, are usually thrown into the genetic trash because they are so similar to each other.
“We didn’t know that mutations in the multicopy tRNA gene could do this,” Ackermann said. “These findings make us think about people who have illnesses with a variety of symptoms and how likely an overlooked gene in this class might play a role in their disease. Is the molecular basis that causes them from behaviors such as seizures.”
The researchers say the results are likely to be the tip of the iceberg, and they are focusing their attention on studying the link of tRNAs to diseases in extracranial tissues.
Source:
See journal:
Kapoor, M. , other (2020) Neuronal tRNA n-Tr20 expression regulates synaptic transmission and seizure susceptibility. Neuron.. doi.org/10.1016/j.neuron.2020.07.023..
..
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
Pictures Credit
to request, modification Contact us at Here or [email protected]
 |
 |
 |
