Health
Here’s how vitamin D levels in the blood predict future health risks, death-health
Recent studies have shown that free circulating vitamin D levels in the blood help to understand and predict future health risks in older men. This suggests that the free precursor form of vitamin D circulating in the bloodstream is a more accurate predictor of future health and disease risk than the frequently measured total vitamin D. I have. , This study suggests that further investigation of vitamin D levels and worsening health status may be a promising area for further study. Vitamin D deficiency is common in Europe, especially in the elderly. It is associated with a high risk of developing many age-related disorders such as cardiovascular disease, cancer and osteoporosis.
However, there are several forms or metabolites of vitamin D in the body, and it is the total amount of these metabolites that is most often used to assess the status of vitamin D in people. The prohormone 25-dihydroxyvitamin D is converted to 1,25-dihydroxyvitamin D, which is considered the active form of vitamin D in the body. Since over 99% of all vitamin D metabolites in our blood are bound to proteins, only a small portion is biologically active. Therefore, free and active forms can be better predictors of current and future health.
Dr. Leen Antonio of Rubens, Belgium’s Rubens Hospital, and a team of colleagues investigated whether free metabolites of vitamin D are good health predictors. , 2003-2005. We compared total and free metabolite levels of vitamin D to current health status and adjusted for potential confounders such as age, body mass index, smoking, and self-reported health. Free Vitamin D and Metabolites The combined levels of both vitamin D metabolites were associated with an increased risk of death. However, only free 25-hydroxyvitamin D predicted future health problems, not free 1,25-dihydroxyvitamin D. Dr. Antonio explains. High risk of death. “
Since this is an observational study, the causal relationship and underlying mechanism remain undecided. It was also not possible to obtain specific information about the cause of death in men in studies that may be confounding factors. “Most studies have focused on the association between total 25-hydroxyvitamin D levels and age-related disease and mortality. Because 1,25-dihydroxyvitamin D is the active form of vitamin D in the body. It could be a more powerful predictor of illness and mortality. It is also debated whether total or free vitamin D levels need to be measured. Currently, our data are available. Both total and free amounts of 25-hydroxyvitamin D suggest better measures of future health risk for men, “says Dr. Antonio. Dr. Antonio and her team are now completing statistical analyzes and writing manuscripts on these findings.
(This article is published from the telegraph agency feed without any changes to the text. Only the headline has changed.)
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