Health
Coronavirus attacks brain cells and reveals new research that can be reproduced with them
Key Point
- A new medical study at Yale University School of Medicine claims that SARS-CoV-2 can infect neurons in the brain
- Further research is needed to identify long-term effects, but this is the first study to confirm this link.
- “If the brain is infected, it can have fatal consequences,” said Dr. Akiko Iwasaki, a Yale immunologist who led the study.
A new medical study found that SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the virus that causes COVID-19, invades the brain and infects neurons and brain cells, resulting in damage and even death. Insist.
A study by researchers at Yale University School of Medicine provides the first “clear evidence of infection and the associated metabolic changes in infected and adjacent neurons.” He also claims that in COVID-19 patients, “SARS-CoV-2 nerve infiltration is associated with mortality, but respiratory infections are not.”
In a Yale study, SARS-CoV-2 forces neurons to proliferate but not destroy them. Instead, this large-scale replication significantly blocks the oxygen supplied to adjacent cells, causing them to die and die.
“These results provide evidence of SARS-CoV-2’s ability to invade neurons and the unexpected consequences of direct neuronal infection with SARS-CoV-2.” Studies show..
It remains unclear how SARS-CoV-2 breaks through the barriers that protect the brain. Brain infections due to SARS-CoV-2 nerve invasion are likely to be rare, but some people may be susceptible to infection due to genetic background, high viral load, or other reasons.
“If the brain becomes infected, it can have fatal consequences,” said Dr. Akiko Iwasaki, an immunologist at Yale who led the study. New York Times..
Her team also found no evidence of an immune response to treat SARS-CoV-2 nerve infiltration in the brain.
“It’s a kind of silent infection,” said Dr. Iwasaki. “There are many evasion mechanisms for this virus.”
Previous studies have shown that some patients with COVID-19 develop serious neurological complications, including nerve damage. However, scientists have previously “not seen much real evidence that the virus can infect the brain, even if they knew it could be potential.” “This data is It certainly provides a little more proof that it is possible. “
Studies have found that SARS-CoV-2 appears to rapidly reduce the number of synapses, or connections between neurons. We also confirmed that SARS-CoV-2 infects cells via ACE2, a protein on the cell surface. This protein is particularly prevalent in the lungs, explaining why it is a more common target for SARS-CoV-2.
“A few days after the infection, synaptic levels have already dropped dramatically,” said Dr. Alysson Muotri, a neuroscientist at the University of California, San Diego. “I’m still not sure if it’s reversible.”
The study, entitled “Nerve Invasion of SARS-CoV-2 in Human and Mouse Brains,” was published last week on the preprinted medical server BioRxiv, but has not yet been investigated.
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