Health
Scientists identify new drugs that may alleviate severe COVID-19
International
pti-madhuri adnal
Los Angeles, September 20: Scientists have discovered that new drugs may prevent or mitigate the serious consequences of COVID-19. This is an advance that may lead to the development of new treatments for coronavirus infections.
Researchers, including researchers at the University of California, Los Angeles (UCLA) in the United States, show how the drug 4-phenylbutyric acid (4-PBA) regulates the inflammatory response that occurs in severe cases of COVID-19 in animal models. Was evaluated.
According to this study, published in the journal Cytokine and Growth Factors Review, the inflammatory process identified in severe cases of COVID-19 causes an uncontrolled excessive release of cytokines, the molecules that organize the body’s defenses.
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Scientists have said that this excessive release can even make blood vessels highly permeable and cause multiple organ failure. They added that controlling the “storm” of such cytokines is essential for treating the severe form of the disease.
“When cells are stressed by infection, they are called cytokines, and the more stress they have, the more persistent they become, causing this chaotic inflammation. Therefore, one possible treatment for COVID-19 is to reduce cell stress. To reduce. “-The author is Ivan Duran of the University of Malaga, Spain.
Duran can divert clinically approved 4-PBA antistress drugs for other diseases to regulate such cellular stress, which is also present in conditions such as diabetes and aging, which are classified as COVID-19 risk factors. Said.
“Our preliminary results in animal models have shown that 4-PBA completely suppresses mortality caused by respiratory failure due to cellular stress,” he added.
According to researchers, their preliminary studies also identified the endoplasmic reticulum resident protein “BiP” (binding immunoglobulin protein) -a stressed blood marker-as an indicator of cellular stress status, and this molecule is also affected. Patient.
Duran found that BiP levels also serve as an early indicator of the COVID-19 risk group, apart from determining the efficacy of 4-PBA treatment, and correlate high levels with the severity of inflammation after viral infection. He said he could. Scientists have pointed out that when infected with the coronavirus, people who are already suffering from a disease that causes cell stress are more likely to get sick or die.
“Therefore, if we know that the patient is suffering from cellular stress, one stone can kill two birds. Know how to detect susceptibility and treat it in a timely manner before the infection occurs. You can, “said UMA scientists.
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