Health

Nitric oxide is a possible treatment for COVID-19, according to research-ScienceDaily

Researchers at Uppsala University have found that effective methods of treating the coronavirus behind the 2003 SARS epidemic also work with the closely related SARS-CoV-2 virus responsible for the ongoing COVID-19 pandemic. I found that I would do it. The substance involved is nitric oxide (NO), a compound with antiviral properties produced by the body itself.The study is published in the journal Redox biology..

“As far as we know, nitric oxide is the only substance that has been shown to have a direct effect on SARS-CoV-2,” said Professor Åke Lundkvist of Uppsala University, who led the study. ..

There is no effective treatment for COVID-19 yet, so the main focus of the tested treatment was on symptom relief. This will reduce hospital stays and reduce mortality. However, so far, it has not been possible to prove that any of these treatments are affecting the actual virus behind the infection.

Nitric oxide (NO) is a compound that is naturally produced in the body. Its functions include acting like hormones that control various organs. For example, it regulates vascular tone and blood flow between and within organs. In acute lung failure, NO can be given as a low concentration of inhaled gas to increase blood oxygen saturation. During the 2003 SARS (Severe Acute Respiratory Syndrome) coronavirus epidemic, this treatment was successfully tested. One important reason for the successful results was a reduction in lung inflammation in the patient. This property of nitric oxide (protection against infection because it is both antibacterial and antiviral) is of current interest to researchers.

Their work is further based on their findings on the coronavirus that caused the first SARS epidemic. In 2003, NO released from S-nitroso-N-acetylpenicillamine (SNAP) proved to have a clear antiviral effect. Researchers at Uppsala University and the Karolinska Institute have investigated how SARSCoV-2, a new coronavirus involved in the current pandemic, reacts to compounds. SNAP also showed a clear antiviral effect against this virus. In addition, the effect became stronger when the dose was increased.

“We hope that inhalation of NO will be an effective treatment until an effective vaccine is available. The dose and timing of starting treatment probably played an important role in the results and are now as soon as possible. We need to investigate, “says Åke Lundkvist.

The research group is currently planning to proceed by investigating the antiviral effects of NO released in the form of gas. To do so, they build a model in the laboratory to safely simulate possible treatments for the patient.

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material Provided by Uppsala University.. Original written by Åsa Malmberg. Note: The content can be edited in style and length.

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