Health
Studies show that the “magic mushroom” ingredient may act as a mental health treatment
Magic mushrooms are known for their hallucinogenic effects, but they can also play a role in some psychiatric treatments. Or, if not illegal in most states, Magic Mushroom became the first state to manufacture psilocybin in the United States. Hallucinogenic Compounds in Magic Mushrooms Legal for Mental Health Treatment in a Monitored Environment They in a new small study of 24 adults with major depression published this week in the journal JAMA Psychiatry. There is evidence of their case that two doses of psilocybin were found. “We saw about four times as much effect as clinical trials of traditional antidepressants on the market,” said Alan, assistant professor of psychiatry and behavioral science. Davis says. In a news statement from Johns Hopkins University School of Medicine. “Most other treatments for depression take weeks or months to be effective and can have unwanted effects. These findings will be found in future” gold standard “placebo-controlled clinical trials. If maintained, this could be a game changer. Although not without restrictions, this study is the latest study to investigate how psilocybin can help alleviate mental health problems. Other studies suggest that this compound may help treat anorexia, obsessive-compulsive disorder, and addiction. Participants in the John Hopkins study experienced depression for about two years before being hired and had to give up existing antidepressants. Thirteen participants received psilocybin treatment immediately after enrollment, and 11 participants were placed on the waiting list and received the same treatment after an eight-week delay. This study provided more evidence of the “quick and powerful effect” of psilocybin. Professor and Director of the Neuropsychopharmacology Unit, Department of Brain Science, Imperial College London. Nat, who was not involved in the study, said the fact that the patient knew he was taking the drug could distort the results and increase the magnitude of the effect. The same Johns Hopkins researcher found that psilocybin can relieve depression and anxiety in patients with life-threatening cancers. “There are several types of major depressive disorders that can change the way people respond to treatment, so I found study participants to be effective with silocibin treatment.” Roland Griffith, author of a new study and 2016 paper, a professor at Johns Hopkins University School of Medicine and director of the Johns Hopkins Psychedelic Consciousness Research Center, said. Studies show that psychedelic therapy can cause severe visual and auditory hallucinations and conscious changes within hours of ingestion. In the United States, possession of a compound is a felony because it is classified as a Schedule I substance. Voting in Oregon The Oregon Department of Health requires that licensed, regulated production and the possession of psilocybin exclusively for administration to clients by licensed facilitators. “Standard antidepressants protect against the stressors that cause and perpetuate depression, but they do not directly access and treat the underlying biopsychosocial causes,” he co-authored in a paper. writing. In contrast, psychedelic therapy utilizes a treatment window opened by the brain through the effects of the drug to promote insight and emotional release. He said the substance tends to function in “internalizing disorders” such as depression and obsessive-compulsive disorder, and individuals tend to ruminate with failure and intrusive thoughts. Another explanation may be simpler. Guy Goodwin, an emeritus professor of psychiatry at Oxford University, said pharmacologically that psilocybin “just kicks the backside” of the serotonin system. Serotonin is a chemical messenger in the digestive, brain and blood systems that regulates mood, social behavior, appetite, sleep, memory and sexual function. Goodwin, who was not involved in the study, stated the main limitation of John Hopkins. The study had no long-term follow-up — the team followed up participants only four weeks after treatment. Depression is a long-term condition for many, and determining whether treatment has had a lasting effect is an important missing factor. In addition, in such studies, it can be difficult to derive the effect of the drug from the process of administration, according to Goodwin, study participants received approximately 11 hours of psychotherapy and the care of trained professionals. Under, received the drug in an environment designed to reassure the patient. “Because everyone is, it works regardless of whether the treatment works. Take care of you, take care of you, measure things. Such people feel that way. , It makes me feel better. In the actual comparison, everything except the actual drug does the same. “But he said extensive research to be addressed is underway. Questions posed by the early proof of such conceptual studies. “This is a great, small preliminary study with many weaknesses, but positive results as well promise better.”
Magic mushrooms are known for their hallucinogenic effects, but they can also play a role in the treatment of mental health.
Or maybe it’s not illegal in most states.
Oregon became the first state in the United States to legally produce psilocybin, a hallucinogen contained in magic mushrooms, for mental health treatments under supervision.
They have more evidence of their case in a new small study of 24 adults with major depression published this week. Journal JAMAPsychiatry, It was found that two doses of psilocybin lead to a significant reduction in depressive symptoms.
Alan Davis, a part-time assistant professor of psychiatry and behavioral science at Johns Hopkins University School of Medicine, said: It was double. ” News statement.
“Most other treatments for depression can take weeks or months to work and can have undesired effects, so if these findings are maintained in future” gold standard “placebo-controlled clinical trials, This can be a game changer. “
Although not without limitations, this study is the latest study to investigate how psilocybin can help alleviate mental health problems. Other studies suggest that this compound may help treat anorexia, obsessive-compulsive disorder, and addiction.
Participants in the John Hopkins study experienced depression for about two years before being hired and had to give up existing antidepressants. Thirteen participants received psilocybin treatment immediately after enrollment, and 11 participants were placed on the waiting list and received the same treatment after an eight-week delay.
The study provided more evidence of the “quick and powerful effect” of psilocybin, said David Nutt, professor and director of the Neuropsychopharmacology Unit of the Brain Sciences Department at Imperial College London. Nat, who wasn’t involved in the study, said the fact that the patient knew he was taking the drug could have distorted the results, and that expectation could increase the magnitude of the effect. Stated.
A 2016 study conducted by several of the same John Hopkins researchers Psilocybin can relieve depression Anxiety of patients with life-threatening cancer.
“Most of our study participants found thyrosibine treatment to be effective because there are several types of major depressive disorders that can change the way people respond to treatment. “I was surprised,” said Roland Griffith, author of the new study, in a 2016 paper, Professor of Johns Hopkins University School of Medicine and Director of the Johns Hopkins Psychedelic and Consciousness Research Center.
Studies have shown that psilocybin can cause severe visual and auditory hallucinations and severe changes in consciousness within hours of ingestion.
In the United States, possession of a compound is a felony and is classified as follows: The entity of Schedule I.
Voting in Oregon requires the Oregon Department of Health to permit licensed, regulated production and possession of psilocybin exclusively for management of clients by licensed facilitators.
How it affects the brain
How psilocybin affects the brain is not yet fully understood, but Imperial College Nat said the compound appears to have disrupted negative thought circuits through the brain’s 5HT2Z receptors. I did.
“Standard antidepressants protect against stressors that cause and perpetuate depression, but they do not directly access and treat the underlying biopsychosocial causes,” he writes. on paper He co-authored and published earlier this year.
“In contrast, psychedelic therapy leverages the therapeutic area opened by the brain through the effects of the drug to promote insight and emotional release.”
He said the substance tends to function in “internalizing disorders” such as depression and obsessive-compulsive disorder, and individuals tend to ruminate with failure and intrusive thoughts.
Guy Goodwin, an emeritus professor of psychiatry at Oxford University, said another explanation could be more easily pharmacological. Psilocybin “just kicks up the back” of the serotonin system, he said. Serotonin is a chemical and neurotransmitter in the digestive, brain and blood systems. It Adjust mood and social behavior, Appetite, sleep, memory and sexual function.
Goodwin, who was not involved in the study, said the main limitation of the John Hopkins study was the lack of long-term follow-up. The team followed up participants only four weeks after treatment. Depression is a long-term condition for many, and determining whether treatment has had a lasting effect is an important missing factor.
In addition, in such studies, it may be difficult to derive the effect of the drug from the process of administering the drug, Goodwin said.
Study participants received approximately 11 hours of psychotherapy and, under the care of a trained professional, received the drug in an environment designed to reassure the patient.
“Everyone takes care of you, cares about you, and measures things, so it works regardless of whether the treatment works. Such people feel it better. In the actual comparison, everything except the actual drug does the same. “
However, he said that larger studies are underway that need to address the questions posed by the early proof of such proof-of-concept studies.
“This is a great little preliminary study with many weaknesses, but positive results as well promise better.”
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