Studies reveal a relationship between gut flora, diet, and illness

A diet rich in plant-based foods promotes the presence of gut flora, which reduces the risk of regular illnesses, including coronary artery disease, according to a study published in Nature Medicine.

The study was led by researchers at King’s College in London, Massachusetts General Hospital (MGH), Harvard University of Public Health, Trent University in Italy, and health startup ZOE.

Extensive global studies using metagenomics and blood compound profiling have revealed a board of 15 gut flora associated with a low risk of normal conditions such as overweight and type 2 diabetes.

PREDICT 1 (personalized response to Dietary Composition Test 1) analyzed detailed data on participants’ intestinal microflora composition, their dietary habits, and cardiac metabolic blood biomarkers. It revealed a strong link between human diet, intestinal microbiomes and their health.

Researchers have identified microorganisms that have a positive or negative correlation between “good” and “bad” with the risk of individuals with certain serious conditions such as diabetes, heart disease, and obesity. Surprisingly, the microbiome is more relevant to these markers than other factors such as genetics. Some of the identified microorganisms are so novel that they have not yet been named.

Researchers have defined a “healthy” diet as containing a mixture of foods associated with a low risk of chronic illness. They found that subjects who ate such a diet, or a plant-rich diet, were more likely to have high levels of certain “good” gut microbes associated with a lower risk of common illness. I found.

Researchers have also discovered microbiome-based biomarkers of obesity, a major risk factor for COVID, as well as markers of cardiovascular disease and impaired glucose tolerance. The results of these findings will help you create a personalized diet plan specifically designed to improve your health.

“As a nutritionist, finding new microbes related to specific food and metabolic health is exciting. Given the highly personalized composition of each individual’s microbes, our study follows gut flora: Optimizes our health by choosing the best foods for our unique biology, suggesting that it could be changed, “said Kings College London, a leader in nutrition science. Dr. Sarabury said.

For example, research results show that having a rich microbial flora of Prevotella copri and Blastocystis species is associated with maintaining good postprandial blood glucose levels. Other species were associated with low postprandial blood fat levels and markers of inflammation.

“When you eat, you not only nourish your body, but also the trillions of microorganisms that live in your gut,” said King’s, the scientific founder of the PREDICT research program. Professor Tim Spector ZO, a college epidemiologist, said.

“I was surprised to see such a large and clear group of microbes that we informally call” good “and” bad “microbes emerge from the analysis. It’s also exciting to see them missing, as microbiologists know very little about many of these microbes. Dr. Nikola Segata, a professor and senior researcher at the Computational Metagenomics Laboratory at Trent University in Italy and a leader in microbiota analysis for this study, said:

“This is currently a major focus for us. In the future, new insights may be opened on how to use the gut flora as a modifiable target to improve human metabolism and health. I think there is, “says Segata.

PREDICT is the world’s largest detailed nutritional research. PREDICT 1 was an international collaborative study to study the links between dietary, microbiome, and cardiac metabolic health biomarkers. The researchers collected microbiome sequence data, detailed long-term dietary information, and the results of hundreds of cardiac metabolic blood markers from more than 1,100 participants. United States and United Kingdom. PREDICT 2 completed its primary survey in 2020 with an additional 1,000 US participants, and PREDICT 3 was launched a few months ago.

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