Study: Deep sleep prevents neurodegenerative diseases that are essential for brain health

A new study led by researchers at Northwestern University emphasizes the importance of getting a deep sleep for brain health.

A study published in Science Advances shows that by examining fruit fly brain activity and behavior, deep sleep has the ancient resilience to remove waste products from the brain. This waste may contain toxic proteins that can lead to neurodegenerative diseases.

“In general, the removal of waste products can be important for maintaining brain health or preventing neurological disorders,” said Dr. Rabbi Arada, senior author of the study. I am. “Excretion removal can occur during awakening and sleep, but is significantly enhanced during deep sleep.”

Allada is a prominent professor of neuroscience at Edward C. Stuntz and chairs the Department of Neurobiology at Northwestern University’s Weinberg University of Arts and Sciences. He is also the Deputy Director of the Center for Sleep and Circadian Biology at Northwestern University. Bart van Alphen, a postdoc in Allada’s lab, was the first author of this treatise.

Drosophila appear to be very different from humans, but the neurons that govern the sleep and wake cycle of flies are very similar to ours. For this reason, fruit flies are well studied as model organisms for sleep, circadian rhythms, and neurodegenerative diseases.

In the current study, Allada and his team examined the deep sleep stage of fruit flies, the tengu extended sleep (PES). This is similar to human deep slow-wave sleep. At this stage, researchers have discovered that fruit flies repeatedly stretch and contract their tengu (or nose).

“This pumping action can move fluid to the fly version of the kidneys,” says Allada. “Our research shows that this facilitates waste removal and helps heal injuries.”

When Allada’s team impaired the flies’ deep sleep, they were unable to remove the infused non-metabolizable dye from the system, making them more vulnerable to trauma.

According to Arada, this study will give a deeper understanding of the mystery of why all living things need sleep. All animals, especially wild animals, are very vulnerable when sleeping. However, studies have increasingly shown that the benefits of sleep, including the removal of significant waste products, outweigh the increased vulnerability.

“Our findings that deep sleep plays a role in fruit fly excretion removal show that excretion removal is an evolutionarily conserved core function of sleep,” the co-author of the paper wrote. I will.

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