Studies show that high blood pressure causes atrial fibrillation

A new study found that hypertension was casually associated with the most common dysregulation.

The results of this study were published in the European Journal of Preventive Cardiology.

The authors of the study, King’s College in London, UK, and Dr. Georgios Georgiopoulos at the National University of Capodistrians in Athens, Greece, said: Individual efforts to control the level. “

Atrial fibrillation is the most common disorder of cardiac rhythm and affects more than 40 million people worldwide. People with disabilities are five times more likely to have a stroke. Previous studies have shown an association between hypertension and the development of atrial fibrillation, but there is no strong evidence of a direct causal relationship.

To investigate whether blood pressure has a direct impact on the risk of atrial fibrillation, researchers conducted a naturally randomized controlled trial called Mendel randomization. They used data from the largest genome-wide association study (GWAS) on blood pressure and atrial fibrillation. This included more than one million individuals of European descent, of which 60,620 had atrial fibrillation and 970,216 had no atrial fibrillation.

The first step was to identify 894 genetic mutations associated with blood pressure. Next, the researchers analyzed which of these mutants play a role in atrial fibrillation. To conduct a naturally randomized controlled trial, 894 genetic mutations were randomly assigned to all participants at conception and each individual was given a blood pressure level. Next, the researchers analyzed the relationship between blood pressure and atrial fibrillation.

Elevated blood pressure was associated with an increased risk of atrial fibrillation. Specifically, 1 mmHg increases in systolic, diastolic, and pulse pressure were associated with a relative increased risk of atrial fibrillation by 1.8%, 2.6%, and 1.4%, respectively.

“The results provide strong evidence of a causal relationship between blood pressure and atrial fibrillation,” said Dr. Georgiopoulos. Using genetic information in the analysis, the reverse causal relationship (that is, atrial fibrillation causes hypertension) or in the atrium Minimize the possibility of other related properties. It was caused by fibrillation (atrial fibrillation). In our study, this relationship was caused by other conditions such as coronary artery disease and obesity. It was shown that it was not a thing. “

“Our findings support the hypothesis that atrial fibrillation is preventable, which means that strict blood pressure control can lead to atrial fibrillation such as stroke, heart failure, dementia, and depression. It shows that it may be an effective strategy to stop the complications. ”

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