Early results suggest that Alzheimer’s drugs may delay cognitive decline in patients

The study included 257 patients with early-stage symptomatological Alzheimer’s disease. 131 received donanemab and 126 received placebo. Researchers found that donanemab delayed cognitive and routine functioning in patients with Alzheimer’s disease by 32% after 76 weeks compared to patients receiving placebo.

Over 18 months, a 32% slowdown in decline could have a significant impact on patients with Alzheimer’s disease, Maria Carillo, chief scientific officer of the Alzheimer’s Disease Association, who was not involved in the study. Says.

“Of the 18 months, these people were slowly declining for 6 months compared to those who didn’t take the drug,” Carrillo said. “It’s six months after better recognition with your family, better memories, and more fun.”

Decline was measured using an integrated Alzheimer’s disease rating scale that measures both cognitive and functional abilities, such as memory and the ability to perform daily tasks.

Carrillo said the results of the Phase 2 trial are early but promising and represent some of the strongest data on the ability of a single drug to slow the progression of Alzheimer’s disease.

“There are many possibilities for this,” Carrillo added. “This could be the first step towards significantly slowing or stopping cognitive decline in these early stages. This will really revolutionize our field.”

The researchers also noted the effect of the drug on the accumulation of amyloid beta plaque and tau protein, which is thought to be characteristic of Alzheimer’s disease.

At 52 weeks, nearly 60% of participants reached amyloid-negative status. This means that the level of participants was otherwise at the level of healthy people. At 76 weeks, the researchers reported that amyloid plaque levels (measured with centiroids) were 85 centiroids lower than those who received placebo.

Patients who reached these low levels of amyloid beta plaque were removed from donammab and given placebo.

Slow down illness

“When these participants removed the amyloid in their brains, the drug was removed and the slowdown was still ongoing,” Carrillo said. “This is important because we cannot continuously monitor safety and adverse events.”

Participants who received donanemab also showed a significant reduction in overall tau load compared to participants who received placebo.

Carrillo said the study was unique in that it screened participants for the presence of both amyloid beta plaque and tau before entering the study.

Some researchers in the field believe that “stopping amyloid early enough and slowing its tau may slow Alzheimer’s disease.” “That’s what this treatise is trying to show, and this is one of the first times we’ve seen it.”

Research on donanemab is still in its infancy, and researchers say longer and larger trials are needed to determine the safety and efficacy of the drug.

Dr. Mark Minton, Eli Lilly’s Vice President of Pain and Neurodegeneration, said: Said in a January statement announcing the test results. Minton said additional ongoing research is aimed at recreating the findings.

No new approved treatments since 2004

The US Food and Drug Administration has not approved a new treatment for Alzheimer’s disease since 2004. Aducanumab, an treatment for Alzheimer’s disease, developed by pharmaceutical company Biogen and its Japanese partner Eisai, is currently under review by the FDA.

Many of the most promising candidates for Alzheimer’s disease are aimed at targeting amyloid beta plaque and tau protein accumulation as they correlate with the progression of Alzheimer’s disease. The goal of drugs such as donanemab is not to cure the disease, but to keep one’s memory and cognition longer.

Alzheimer’s disease is the most common form of dementia and currently affects 6.2 million Americans over the age of 65, according to the Alzheimer’s Association. By 2060, that number is expected to grow to at least 14 million, according to the US Centers for Disease Control and Prevention.

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