Health
A lacrimal gland is created.Breakthrough may mean treatment of eye disorders
Thursday, March 18, 2021
A team of researchers used a 3D technique called organoids to create miniature lacrimal glands that could mimic the function of organs and shed tears. This advance helps analyze painful and susceptible eye diseases, such as so-called dry eye disease. The study was developed by an team of biologist Hans Clevers at the University Medical Center in Utrecht (Netherlands).
The lacrimal gland is located in the upper part of the orbit and its function is to smooth and protect the cornea. Due to its location, studying it is not easy for professionals.
During the project, researchers created human and mouse glands on laboratory dishes and exposed organoids to a variety of chemicals to stimulate tear production. “Organoids grow using growth-stimulating cocktails. We had to change our regular cocktails to cry,” explained researcher Marie Banier Elaue.
Organoids do not have tubes, so they swell when tears come out. “If there were a small duct, there would have been water droplets,” Clevers added. In addition, when organoids were transplanted into mice, they matured and developed structures similar to the protein-containing ducts found in tears.
The research team is currently working on lacrimal glands and hopes to find new drugs for patients with tear developmental disorders. “For example, lacrimal gland dysfunction in Sjogren’s syndrome can have serious consequences, such as dry eye and corneal ulcers, which in severe cases can lead to blindness,” said ophthalmologist Rachel.・ Kalman explained. the work.
Bannier-Hélaouët concluded, “We hope that this type of organoid can be transplanted into patients with non-functioning lacrimal glands.” (Text and photos: RT)
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