Health
Viagra may extend the lifespan of men with coronary artery disease
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Men with stable coronary artery disease who are taking Viagra for impotence appear to live longer and have a lower risk of experiencing a new heart attack, a study by the Karolinska Institute in Sweden Journal of American Universities of Cardiovascular Report.
Impotence may be an early warning sign of cardiovascular disease Healthy man It is then treated topically with alprostadil. Blood vessels Taken orally in the form of tablets before gender to stiffen the penis, or using so-called PDE5 inhibitors such as Viagra and Cialis, to inhibit the enzyme phosphodiesterase 5 (PDE5) in the penis and increase blood flow Let me do it.
Previously, PDE5 inhibitors lower blood pressure Coronary artery disease Because of the risk of heart attack..
However, in 2017 Martin Holzmann and colleagues showed that men with a heart attack tolerate the drug well, prolong life expectancy, and protect against new infarctions and heart failure.
In their new study, researchers sought to compare the effects of alprostadil and PDE5 inhibitors in men with stable coronary artery disease.The patient has an infarction, balloon dilation, or Coronary artery bypass surgery At least 6 months before the start of treatment for erectile dysfunction.
“The risk of a new heart attack is greatest in the first six months, after which coronary artery disease appears to be stable,” said Martin, adjunct professor at the Karolinska Institute’s Solna Medical School. Holtzmann says.
The registry study consisted of 16,500 men treated with PDE5 inhibitors and just under 2,000 men treated with alprostadil. Data were collected from patient, drug, and cause of death registries.
In this study, men who received PDE5 inhibitors lived longer and Low risk Patients receiving alprostadil have a higher rate of new heart attacks, heart failure, balloon dilatation, and bypass surgery. The higher the dose of PDE5 inhibitor, the lower the risk, because the protection was dose-dependent.
“is this, Causal relationshipBut registry research can’t answer that question, “Holtzmann said. Patients should be randomly assigned to two groups to see if the drug reduces the risk. One takes PDE5 and the other does not. The results we have just obtained give us a very good reason to undertake such research. “
PDE5 inhibitors are not available over-the-counter as they are available prescription only in Sweden, but Holtzmann hopes that men with coronary artery disease will not hesitate to consult a doctor.
“Efficacy problems are common in older men, and our research now also shows that PDE5 inhibitors can prevent heart attacks and prolong lifespan,” he says.
“Phosphodiesterase-5 inhibitor vs. alprostadil associated with survival in men with coronary artery disease”. Daniel P Andersson, Laura Landucci, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J Holzmann Journal of American Universities of Cardiovascular, Online March 22, 2021 DOI: 10.1016 / j.jacc.2021.01.045
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Karolinska Institute
Quote: Viagra is a coronary artery disease acquired on March 22, 2021 from https://medicalxpress.com/news/2021-03-viagra-prolong-life-men-coronary.html (March 22, 2021) May extend the lifespan of men
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